Variable Pressure Support Ventilatio

Completed

Conditions: delayed weaning from mechanical ventilation
10024967

Registration Number: NL-OMON38687

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 50

Inclusion Criteria

* Age * 18 years
* Duration of controlled mechanical ventilation * 24h
* Availability of a Infinity V500 ventilator (ready to use)
* Informed consent according to local regulations
* Temperature * 39 °C
* Hemoglobin * 6 g/dl
* PaO2/FIO2 * 150 mmHg with positive end-expiratory pressure (PEEP) *16 cmH2O
* Ability to breath spontaneously

Exclusion Criteria

* Participation in another interventional trial within the last four weeks before enrollment in this trial
* Peripheral neurological disease associated with impairment of the res-piratory pump
* Muscular disease associated with impairment of the respiratory pump
* Instable thorax with paradoxical chest wall movement
* Planned surgery under general anesthesia within 72 hours
* Difficult airway/intubation
* Existing tracheotomy at ICU admission
* Expected survival < 72 hours
* Home mechanical ventilation or on chronic oxygen therapy
* Suspected pregnancy

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Weaning time defined as time from randomization to successful extubation. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>* total time of mechanical ventilation<br /><br>* length of stay in the ICU and in-hospital<br /><br>* mortality<br /><br>* lung function<br /><br>* patient comfort<br /><br>* organ failure<br /><br>* need for noninvasive ventilation and reintubation;<br /><br>* number of interventions of the ICU personal in the mechanical ventilator;<br /><br>* variability of respiratory parameters of the breathing pattern</p><br>