The Dual Impact of Cirrhosis on Transplantation for Hepatocellular Carcinoma：a Two-center Retrospective Cohort Study in China

Completed

• Conditions: Hepatocellular Carcinoma; Cirrhosis

• Registration Number: NCT06420791
• Lead Sponsor: Xiao Xu

Brief Summary

Background: This study aims to investigate the correlation between cirrhosis and hepatocellular carcinoma (HCC) recurrence after Liver Transplantation.

Methods: The study retrospectively collected data enrolled from 519 HCC patients who underwent liver transplantation from two center(the First Affiliated Hospital, Zhejiang University School of Medicine and Shulan (Hangzhou) Hospital, January 2015 to December 2020), Based on important variables, 1:3 propensity score matching (PSM) were performed respectively.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-02-28
• Status Verified: 2024-05
• Primary Completion: 2024-05-03
• Study Completion: 2024-05-06
• Study First Submitted: 2024-05-14
• Study First Submitted QC: 2024-05-14
• Last Update Submitted: 2024-05-14
• Study First Posted: 2024-05-20
• Last Update Posted: 2024-05-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1

Inclusion Criteria

The patients undergoing liver transplantation for HCC from January 2015 to December 2020.

Exclusion Criteria

Re-transplantation or combined liver-kidney transplantation; incomplete laboratory or clinical data; death within 90 days.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The overall survival rate was evaluated by follow-up investigation and outpatient review	2-5 years

Secondary Outcome Measures

Name	Time	Method
The tumor-free survival rate was evaluated by follow-up investigation and outpatient review	2-5 years

Trial Locations

Locations (1)

Zhejiang University school of Medicine; 🇨🇳 Hangzhou, Zhejiang, China