Interaction of Chronic Sleep Restriction and Circadian Misalignment on Sleep and Neuro-cognitive Performance

Not Applicable

Completed

• Conditions: Healthy

• Registration Number: NCT00438438
• Lead Sponsor: Brigham and Women's Hospital

Brief Summary

The primary objectives of the proposed experimental and modeling efforts are to quantify the influences of acute sleep deprivation (short-term homeostatic), chronic sleep restriction (long-term homeostatic), circadian rhythmicity, and their interactions on neurocognitive performance and to develop a new model of sleep homeostasis that can predict the effects of chronic sleep restriction. This model will be based on the underlying neuroanatomy and neurophysiology. This new model will facilitate optimization of human performance in operational settings, such as are seen in military operation and other work environments.

Detailed Description

This protocol involves a baseline period consisting of 14 hours of wakefulness and 10 hour nocturnal sleep episodes each 24 hours. This is followed by a forced desynchrony regimen spanning 21 calendar days and consisting of 12 cycles ("days") of a 42.85-hour wake:bedrest schedule. In each 42.85 hour cycle, there are 32.85 hours of scheduled wakefulness and 10 hour sleep opportunities. This will allow assessment of the independent contributions of circadian phase and homeostatic sleep pressure on sleep and neurobehavioral performance. This forced desynchrony regimen is followed by 10 recovery days consisting of 14 hours of wakefulness and 10 hour nocturnal sleep episodes each 24 hours.

Study Timeline

• Study Start: 2006-04
• Study First Submitted: 2007-02-20
• Study First Submitted QC: 2007-02-21
• Study First Posted: 2007-02-22
• Primary Completion: 2008-11
• Study Completion: 2008-11
• Status Verified: 2011-08
• Last Update Submitted: 2011-08-31
• Last Update Posted: 2011-09-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 9

Inclusion Criteria

• Age 18-35 years old
• Medically healthy

Exclusion Criteria

• Sleep disorder
• Psychiatric illness
• Chronic medical condition
• No prescription or Non-prescription medications

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Sleep Stage	38 days
Circadian Phase (melatonin rhythm)	38 days
Psychomotor Vigilance Task	38 days
Digit Symbol Substitution Task	38 days
Addition Task	38 days
Karolinska Sleepiness Scale	38 days
Karolinska Drowsiness Test	38 days
Mood Scales	38 days
Flanker Task	38 days
Multiple Object Tracking	38 days

Trial Locations

Locations (1)

Brigham and Woman's Hospital; 🇺🇸 Boston, Massachusetts, United States