"Interaction of Chronic Sleep Restriction and Circadian Misalignment on Sleep and Neuro-cognitive Performance"
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 2
- 主要终点
- Multiple Object Tracking
研究概览
简要总结
The primary objectives of the proposed experimental and modeling efforts are to quantify the influences of acute sleep deprivation (short-term homeostatic), chronic sleep restriction (long-term homeostatic), circadian rhythmicity, and their interactions on neurocognitive performance and to develop a new model of sleep homeostasis that can predict the effects of chronic sleep restriction. This model will be based on the underlying neuroanatomy and neurophysiology. This new model will facilitate optimization of human performance in operational settings, such as are seen in military operation and other work environments.
详细描述
This protocol involves a baseline period consisting of 14 hours of wakefulness and 10 hour nocturnal sleep episodes each 24 hours. This is followed by a forced desynchrony regimen spanning 21 calendar days and consisting of 12 cycles ("days") of a 42.85-hour wake:bedrest schedule. In each 42.85 hour cycle, there are 32.85 hours of scheduled wakefulness and 10 hour sleep opportunities. This will allow assessment of the independent contributions of circadian phase and homeostatic sleep pressure on sleep and neurobehavioral performance. This forced desynchrony regimen is followed by 10 recovery days consisting of 14 hours of wakefulness and 10 hour nocturnal sleep episodes each 24 hours.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-35 years old
- •Medically healthy
排除标准
- •Sleep disorder
- •Psychiatric illness
- •Chronic medical condition
- •No prescription or Non-prescription medications
结局指标
主要结局
Multiple Object Tracking
时间窗: 38 days
Flanker Task
时间窗: 38 days
Sleep Stage
时间窗: 38 days
Circadian Phase (melatonin rhythm)
时间窗: 38 days
Psychomotor Vigilance Task
时间窗: 38 days
Digit Symbol Substitution Task
时间窗: 38 days
Addition Task
时间窗: 38 days
Karolinska Sleepiness Scale
时间窗: 38 days
Karolinska Drowsiness Test
时间窗: 38 days
Mood Scales
时间窗: 38 days
次要结局
未报告次要终点
研究者
Elizabeth B. Klerman
Associate Professor, Associate Physician
Brigham and Women's Hospital