Serpin C and Soluble Fms-like Tyrosine Kinase-1 Levels in Normotensive Pregnant Women May Predict the Development of Preeclampsia
Completed
- Conditions
- Pre-Eclampsia
- Registration Number
- NCT06214702
- Lead Sponsor
- Benha University
- Brief Summary
Evaluation of the predictability of estimated levels of Serpin C, sFlt-1 and placental growth factor (PLGF) in blood samples obtained during the 1st trimester from normotensive pregnant women for identification of women liable to develop PE during the course of pregnancy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 60
Inclusion Criteria
- Normotensive pregnant women had singleton fetus presenting during the 1st trimester
- free of exclusion criteria
Exclusion Criteria
- Age
- Sex
- Hypertension
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Role of Biomarkers in detection of GHTN 9 months The predictability of serum biomarkers' levels estimated at enrolment for the development of GHTN.
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular pathways connect Serpin C and sFlt-1 dysregulation to preeclampsia pathogenesis in normotensive pregnancies?
How do sFlt-1 and PLGF levels in first-trimester blood samples compare to standard preeclampsia prediction biomarkers like uterine artery Doppler?
Which biomarker combinations (Serpin C, sFlt-1, PLGF) optimize early preeclampsia risk stratification in normotensive women?
What adverse pregnancy outcomes correlate with elevated sFlt-1/Serpin C ratios in NCT06214702's observational cohort?
Do sFlt-1 and Serpin C assays outperform existing predictive models (e.g., MAPS, sPLA2) for early-onset preeclampsia detection?
Trial Locations
- Locations (1)
Banha University
🇪🇬Banhā, El- Qalyobia, Egypt
Banha University🇪🇬Banhā, El- Qalyobia, Egypt