Impact of Acute Hospitalisation and Resistance Training on Muscle Architecture and Physical Performance in Older Adults

Not Applicable

Recruiting

Conditions: Sarcopenia
Acutely Ill
Resistance Training
Functional Decline
Ultrasound
Physical Performance
Muscle Architecture
Hospitalisation
Gait Speed
Older Adults

Brief Summary: Sarcopenia characterised by loss of muscle mass, muscle strength and physical performance burdens many older adults since the condition is related to functional decline. Periods of inactivity such as during hospitalisation leads to further functional decline. It has been reported that the loss of muscle mass associated with sarcopenia not only entails a decrease in muscle mass but also changes in muscle architecture. Knowledge on changes in muscle architecture is essential since it is one of the most important determinants on muscle strength and thus physical performance. The main objective of this study is to investigate changes in muscle architecture and physical performance during acute hospitalisation and after discharge in older adults and subsequently the effectiveness of resistance training of the lower limb during acute hospitalisation. If successful, our study could have a great impact on the individual, as well as societal level, due to a better understanding of the factors related to sarcopenia and the prevention of functional decline as a result of hospitalisation.

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

Able to ambulate without assistance during current hospitalization
Known severe dementia
Positive Confusion and Assessment Method score
Patients who have received less than 3 resistance training sessions at discharge
Terminal illness
Recent major surgery or lower extremity bone fracture in the last 3 months
Conditions contradicting use of ROBERT(unstable vertebral-, pelvic, or lower extremity fractures
high intracranial pressure
pressure ulcers or risk of developing pressure ulcers due to fragile skin
patients with medical instability)
Metastases at femur hip
Deemed not suitable for resistance training sessions with the robot by the healthcare professional.

Arm && Interventions

Group	Intervention	Description
Intervention Group	Resistance training	Group of participants receiving resistance training during hospitalisation
Control Group	Resistance training	Group of participants receiving sham training during hospitalisation

Primary Outcome Measures

Name	Time	Method
Change from baseline 4 meter Gait Speed Test	Change from baseline (day of hospitalisation) to 1-month follow-up and 3-months follow-up	Physical performance evaluated by the 4m Gait Speed test
Change from baseline B-mode ultrasonography	Change from baseline (day of hospitalisation) to 1-month follow-up and 3-months follow-up	Muscle architecture of the muscle vastus lateralis assessed with B-mode ultrasonography.

Secondary Outcome Measures

Name	Time	Method
Change from baseline 30s Chair Stand test	Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week)	Maximal muscle strength of the lower extremities evaluated by the 30s Chair Stand Test or the m30s Chair Stand Test (Modified).
Length of hospital stay	Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week)	Number of days hospitalised
Mortality	Baseline (day of hospitalization) to 3-months follow-up	Administrative registers will be used to assess mortality
Change from baseline Barthel-Index 100 (Shahs version)	Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week)	Functional level evaluated by The Barthel-Index 100 (Shahs version)
Individual level of physiotherapy	Baseline (day of hospitalisation) to 3-months follow-up	Adminstrative registers and municipalities health records will be used to assess the individual level of physiotherapy (minutes of consultation) in the period of inclusion.
Change from baseline Bioimpedance	Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week)	Muscle quantity (kg) on wholebody level evaluated by Bioimpedance
Unplanned hospitalisation	Day of discharge from hospital to 3-months follow-up	Patients will be followed through a review of medical records for any unplanned Adminstrative registers will be used to assess any unplanned hospitalisation during the period of inclusion.

Locations (1): Geriatric Deparment OUH Svendborg Hospital
🇩🇰
Svendborg, FYN, Denmark