Chinese Observational Prospective Study of Aging Population With Chronic Kidney Disease(C-OPTION)
- Conditions
- Chronic Kidney Disease
- Registration Number
- NCT03246204
- Lead Sponsor
- Chinese PLA General Hospital
- Brief Summary
The study is an observational, multicenter, prospective cohort study aimed at evaluating a 5-year screening programme for chronic kidney disease(CKD) in a population of elderly patients, aged 65 years or more, in China.To analyze the etiology and composition spectrum, the incidence of complications and co-morbidities.To assess the correlation between daily living ability, mental and physical function, quality of life, nutritional status and prognosis.To develop biomarkers of renal aging.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 3000
Inclusion Criteria
- age≥65 years
- clinical diagnosis of CKD
- signed informed consent
Exclusion Criteria
- subjects who have a poor compliance and cannot be scheduled for follow-up
- subjects participating in other interventional clinical trials
- ESRD or dialysis
- Acute kidney injury(AKI)
- history of solid organ or bone marrow transplantation
- active malignancy within 24 months prior to screening or metastatic cancer
- life expectancy less than 6 months；
- severe cognitive impairment（NYHA III or IV）
- HIV infection or AIDS
- subjects cannot be able to complete the assessment including dementia or other mental disorders, limited physical activity, severe visual impairment
- simple hematuria
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method eGFR decline≥40% 5 year Death 5 year Incidence of End Stage Renal Disease (ESRD) 5 year ESRD will be defined as estimated glomerular filtration rate(eGFR)\<15 mL/min/1.73 m2 or dialysis
- Secondary Outcome Measures
Name Time Method Heart failure 5 year Acute coronary syndrome 5 year Peripheral arterial disease 5 year Cerebral stroke 5 year