The Effect of Music on Functional Processing and Structural and Functional Development of the Preterm Infant's Brain

Pediatric Clinical Research Platform1 site in 1 country63 target enrollmentMarch 1, 2013

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Prematurity
Sponsor: Pediatric Clinical Research Platform
Enrollment: 63
Locations: 1
Primary Endpoint: Compare resting state maturation in the three groups using resting state fMRI
Status: Recruiting
Last Updated: 2 years ago

Studying the effect of music intervention on preterm infants' brain development by MRI and neurodevelopmental assessments

Registry

clinicaltrials.gov

Start Date

March 1, 2013

End Date

December 31, 2025

Last Updated

2 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Sponsor

Pediatric Clinical Research Platform

Responsible Party

Sponsor

•Neurological issues or malformations (such as III-IV stade Intraventricular hemorrhage, micro or macrocephaly, hydrocephaly...)
•Because of the high noise caused by nasal continuous positive airway pressure (nCPAP), preterm newborns without at least nCPAP pause before 32 6/7 gestational age will be excluded

Compare resting state maturation in the three groups using resting state fMRI

Time Frame: 40 weeks gestational age

An MRI will be conducted at term or term equivalent age including resting state functional magnetic resonance imaging (fMRI) measures.

Compare structural maturation in the three groups using structural MRI and DTI

Time Frame: 40 weeks gestational age

An MRI will be conducted at term or term equivalent age including structural Magnetic Resonance Imaging and Diffusion Tensor Imaging (DTI) measures.

The music intervention effect on effortful control at one and two years of age(at 2 years of age)
Functional responses to known and unknown music in preterm infants with music intervention will be compared to no-intervention groups responses using fMRI(40 weeks gestational age)
The music intervention effect on cognitive language and motor development at one and two years of age(at 1 and 2 years of age)
The music intervention effect on emotion and temperament at one and two years of age(at 1 and 2 years of age)
Functional responses to known and unknown music in preterm infants with music intervention will be compared to no-intervention groups responses using EEG(40 weeks gestational age)