Comparing the Efficacy of Perioperative Pain Control Between Intravenous Parecoxib and Oral Etoricoxib in ACL Reconstruction: A Randomized Controlled Trial

Faculty of Medicine, Prince of Songkla University0 个研究点目标入组 160 人开始时间: 2023年9月16日最近更新: 2024年8月19日

适应症

试验速览

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•The patients diagnosed as anterior cruciate ligament injury aged 18-50 years old who scheduled for arthroscopic ACLR.

•1. Patient who schedules for bone-patellar tendon-bone autograft ACL reconstruction
•2. Allergy to acetaminophen, aspirin, sulfonamide, NSAIDs or opioids
•3. History of dyspepsia, peptic ulcer, or abnormal bleeding
•4. History of ASCVD (History of diagnosis ACS, clinical likely ACS)
•5. History of CKD
•6. History of asthma or COPD because selective COX-inhibitor induce spasm
•7. History of cerebrovascular disease
•8. History of peripheral arterial disease
•9. Patients who have Kratom or Marijuana used or substance abuse
•10. Patients who anesthesiologist concerns the risk of general anesthesia (GA) is higher than spinal anesthesia; hence, they prefer to use spinal anesthesia rather than general anesthesia
•11. Pre-operative abnormal EKG or laboratory result e.g., high Cr clearance, abnormal coagulogram

发起方

Faculty of Medicine, Prince of Songkla University