NAD Therapy for Improving Memory and Brain Blood Flow in Older Adults With Mild Cognitive Impairment
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- Cognitive Scores at Baseline and Week 12
研究概览
简要总结
This study will provide insight into whether a nutritional supplement, nicotinamide riboside (NR), improves memory and brain blood flow in older adults with low memory abilities. Overall, this project has the potential to identify a novel, safe and cost-effective strategy for decreasing age-related memory loss.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
盲法说明
Double-blind
入排标准
- 年龄范围
- 60 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Placebo
placebo
干预措施: Placebo (Other)
Nicotinamide Riboside
Niagen® (ChromaDex, Inc.) 500 mg, twice daily
干预措施: Niagen® (Drug)
结局指标
主要结局
Cognitive Scores at Baseline and Week 12
时间窗: baseline and 12 weeks
Primary outcome was a change from baseline in any domain of cognitive function. For all outcomes, a higher score indicates better cognitive function: 1. California Verbal Learning Test III (CVLT-III) Index Scores. Ability learn and recall a list of words over 5 trials and again after a 20 minute delay. Each Index Score has a mean of 100 and a standard deviation of 15 based on normative dataset (Range = 55 - 145). 2. Wechsler Memory Scale IV (WMS-IV) Raw Scores. * Logical Memory I \& II: Range = 0-50 * Logical Memory II Recognition: Range = 0-30 * Visual Reproduction I \& II: Range = 0-43 * Visual Reproduction II Recognition Score: Range = 0-7 3. NIH Toolbox Fluid Composite Score. Composite Score has a mean of 100 and a standard deviation of 15 based on normative dataset (Range = 55 - 145) - based on several tests of fluid and crystallized cognition (episodic memory, attention, working memory, processing speed, executive function and language abilities).
次要结局
- Cerebrovascular Reactivity at Baseline and 12 Weeks(baseline and 12 weeks)
- Total Brain Blood Flow at Baseline and 12 Weeks(baseline and 12 weeks)
- Aortic Stiffness at Baseline and 12 Weeks(baseline and 12 weeks)
- Blood Pressure at Baseline and 12 Weeks(baseline and 12 weeks)
研究者
Christopher Martens
Assistant Professor
University of Delaware