Pharmacokinetics and pharmacodynimics of intravenous acetaminophen in Japanese surgical patients
Not Applicable
- Conditions
- Patients who undergo surgeries under general anesthesia
- Registration Number
- JPRN-UMIN000013418
- Lead Sponsor
- Anesthesiology, Fukushima Medical University
- Brief Summary
sing 185 datapoints from 12 patients, the pharmacokinetics of i.v. acetaminophen were described by a two compartment model with weight as a covariate. The pharmacokinetic model of i.v. acetaminophen reported by Wurthwein et al.(Eur J Clin Pharmacol.2005;60:883) worked well. Above pharmacokinetic analysis was published as a final result. (J Anesth, DOI 10.1007/s00540_017_2358_7)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Not provided
Exclusion Criteria
1.Known allergy to acetaminophen 2.Psychoneurotic disorders 3.Psychiatric pharmacotherapy 4.Chronic use of ACET, NSAIDs or opioids 5.Women who were pregnant or breast-feeding 6.Anemia 7.Liver or advanced renal dysfunction 8.Those who were considered inadequate
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method