A Clinical Study of the Efficacy of Fuzhenghuayu Granules Combined with Losartan in the Treatment of Primary Glomerulonephritis

Shuguang Hospital affillated with Shanghai University of TCM0 个研究点开始时间: 待定最近更新: 2023年2月20日

适应症

试验速览

暂无简介。

•1. Aged from 18 to 65 years;
•2. Diagnosed with primary glomerulonephritis and included in the period of CKD G3;
•3. 0.5g <= 24 h proteinuria <= 3.0g;
•4. Blood pressure can be controlled under 140/90mmHg;
•5. Severe infection, electrolyte disorders or acid-base disturbance can be controlled while the blood potassium value is within the normal range;
•6. Traditional Chinese medicine syndrome conform liver-kidney yin deficiency;
•7. Run-in period: two weeks. At the beginning and end of the run-in period, patients must undergo the following tests twice, and only those who meet the standards can enter the trial. GFR: 3059 mL/min/1.73m2, 0.5g <= 24 h proteinuria <= 3.0g, Bp <= 140/90 mmHg;
•8. Obtain the agreement of patients, and signed informed consent file.

•1. Henoch-Schonlein purpura nephritis, lupus nephritis, systemic small vasculitis kidney damage, gouty nephropathy, Myeloma nephropathy and other secondary nephropathy;
•2. Take the glucocorticoid, immunosuppressants and triptolide medications in the last 3 months;
•3. Take other Chinese patent medicine and decoction whicn can reduce proteinuria in the last 2 weeks;
•4. Combined with severe primary disease of heart, brain, liver and hematopoietic system, or other serious diseases can affect patients life;
•5. Pregnant or lactating women;
•6. Allergic predisposition or known to be allergic to the drug composition;
•7. Blood presser < 90/60mmHg;
•8. Patient with unilateral or bilateral renal artery stenosis;
•9. Patients with mental disorders and poor compliance;
•10. Patiens are suspected or confirmed with alcohol, drug abuse history;
•11. Patines who is participating in another clinical study at the same period.

发起方

Shuguang Hospital affillated with Shanghai University of TCM