NCT02885558CompletedNot Applicable
Role of T-type Calcium Channels in Vascular Function
University of Southern Denmark2 sites in 1 country12 target enrollmentStarted: November 1, 2017Last updated:
Conditions
Interventions
Drugs
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 12
- Locations
- 2
- Primary Endpoint
- Vascular function
Study Overview
Brief Summary
The purpose of this study is to examine the role of T-type calcium channels in endothelial dysfunction observed with ageing.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 20 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •age 20 - 30 and 60-70
- •BMI < 30
Exclusion Criteria
- •Hypertension (>150/90 mmHg)
- •Physical activity >2 hours/week
- •Known chronic diseases
- •Pregnancy or birth within 3 month
- •Alcohol misuse
Arms & Interventions
L + T-type
Experimental
8 weeks treatment with efonidipine (1 week 1x20mg, 7 weeks 2x20mg)
Intervention: Efonidipine (Drug)
L-Type
Active Comparator
8 weeks treatment with nifedipine (1 week 1x20mg, 7 weeks 2x20mg)
Intervention: Nifedipine (Drug)
Outcomes
Primary Outcomes
Vascular function
Time Frame: 8 weeks
Hemodynamic response to femoral arterially infused vasoactive substances
Secondary Outcomes
No secondary outcomes reported
Investigators
Stefan Mortensen
Associate Professor
University of Southern Denmark
Study Sites (2)
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