A randomised controlled trial to evaluate the effect of inhaled glycopyrrolate in improving the fibreoptic intubating conditions under general anaesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- To evaluate and compare the degree of airway secretion with or without use of inhaled glycopyrrolate prior to fibreoptic intubation
研究概览
简要总结
In this study, inhaled glycopyrrolate is used as a premedication inorder to reduce the airway secretions to improve the fibreoptic visual field during nasotracheal intubation.
According to DAS guidelines for awake tracheal intubation,use of systemic antisialogogue is not mandatory, however its also stated that fibrescopy view may be improved with antisialogogue.
Inhaled glycopyrrolate ,currently approved for management of COPD has not been evaluated for its anti secretory effect.Hence usage of inhaled glycopyrrolate is expected to have less systemic side effects and thus can be a better alternative to systemic antisialogogue.
研究设计
- 研究类型
- Interventional
- 分配方式
- Permuted block randomization, fixed
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA physical status 1 and 2 of either sex undergoing elective surgery Age of 18 to 65 years Anticipated difficult airway in which fibreoptic intubation is planned under general anaesthesia.
排除标准
- •Patients in which other modalities of intubation is planned Airway obstruction.
结局指标
主要结局
To evaluate and compare the degree of airway secretion with or without use of inhaled glycopyrrolate prior to fibreoptic intubation
时间窗: Intraoperative at the time of fibreoptic intubation
次要结局
- Time to reach carina(The change in heart rate and blood pressure 20 min after nebulization)