Functional Antigen Matching in Corneal Transplantation
Not Applicable
Completed
- Conditions
- Corneal Diseases
- Registration Number
- NCT00810472
- Lead Sponsor
- University Hospital Freiburg
- Brief Summary
Penetrating keratoplasty is one of the most commonly performed transplantation surgeries. Graft rejection is a major complication. HLA compatibility has already been demonstrated an effective prophylaxis in several retrospective investigations. The purpose of the investigators randomized clinical trial is to demonstrate superiority of HLA matching in comparison to random graft assignment with respect to the endpoint 'time to first endothelial graft rejection' in penetrating keratoplasty. The investigators will perform DNA-based allele resolution typing.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 650
Inclusion Criteria
- Predicted waiting time for a 4/6 match lower than 6 months.
Exclusion Criteria
- Minority
- Legal incapacity
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Time to first endothelial graft rejection. Mostly within the first six months.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University Eye Hospital Freiburg
🇩🇪Freiburg, Baden-Württemberg, Germany
University Eye Hospital Freiburg🇩🇪Freiburg, Baden-Württemberg, Germany