Procalcitonin Level as a Surrogate for Catheter-related Blood Stream Bacteremia Among Hemodialysis Patients

Completed

• Conditions: Hemodialysis Catheter Infection

• Registration Number: NCT03039777
• Lead Sponsor: Benha University

Brief Summary

Hemodialysis patients frequently develop catheter-related blood stream bacteremia (CRBSI). Procalcitonin is a marker of sepsis in bacterial infection. this study for detection of its role as a surrogacy marker in CRBSI.

Detailed Description

Catheter-related blood stream bacteremia is common among hemodialysis patients. Clinically, fever and/or rigors with laboratory indicator of inflammation as leucocytosis and elevated c-reactive protein level are considered as markers for CRBSI before blood culture results became available.

Procalcitonin is a valid indicator of sepsis. In this study, Procalcitonin level will be measured in any patient with suspected CRBSI and correlation will be tested for proved CRBSI by blood cultures.

Study Timeline

• Study Start: 2016-09-01
• Study First Submitted: 2017-01-30
• Study First Submitted QC: 2017-01-31
• Study First Posted: 2017-02-01
• Primary Completion: 2017-02-28
• Study Completion: 2017-03-01
• Status Verified: 2017-07
• Last Update Submitted: 2017-07-13
• Last Update Posted: 2017-07-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• Hemodialysis patients with a dialysis catheter
• signs suggestive of CRBSI: fever/chills or leucocytosis with no other site of infection.
• Informed consent signed to be enrolled in the study

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Exclusion Criteria

• Patient with identified cause of fever other than CRBSI

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Procalcitonin Level	2 minutes after start of fever/chills or other symptoms suggesting CRBSI	Level of serum procalcitonin

Trial Locations

Locations (1)

New jeddah clinic Hospital; 🇸🇦 Jeddah, Saudi Arabia