The Association of Protein-Energy Adequacy With Mortality in Critically Ill Patients With Acute Kidney Injury. A Prospective Observational Single- Centre Study.
试验速览
- 阶段
- 不适用
- 入组人数
- 185
- 试验地点
- 1
- 主要终点
- 28-Days Mortality
研究概览
简要总结
This is a prospective observational single-center study in which the association of Protein-Energy Adequacy and 28-Days of Mortality among critically ill patients with Acute Kidney Injury, AKI will be investigated. The association of Protein-Energy adequacy with a length of ICU and hospital stay, total ventilator, and inotropic drug days among critically ill patients with AKI also will be investigated.
详细描述
Patients with Acute Kidney Injury, AKI are probably more exposed to the risk of malnutrition especially if they undergo Renal Replacement Therapy, RRT. Optimization of nutrients especially energy and protein can ensure a better health outcome for critically ill patients with AKI. Moreover, there is no research on the association of Protein- Energy adequacy with mortality among critically ill patients with AKI in Malaysia. So, the main purpose of this study is to investigate the relationship of Protein-Energy adequacy with mortality among critically ill patients with AKI
Subjects will be recruited upon admission in ICU after fulfilling the inclusion and exclusion criteria. They will be follow up from day 1 until day 14 or until ICU Discharge. Data including Demographic, Clinical, Laboratory, and Nutritional Status will be recorded. On Day 28, the outcome data including Mortality, length of ICU Stay, and Length of Ventilator day will be recorded.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who are 18 years old and older
- •Patients who are admitted to the participating ICU.
- •Patients who are mechanically ventilated.
排除标准
- •Patients who are less than 18 years old
- •End-stage renal disease patients
- •Patients undergo kidney transplantation within 3 months before ICU admission
- •Pregnant patients
- •The patient is moribund with expected death within 24 hour or whom survival to 28 days is unlikely due to uncontrollable comorbidity (cardiac, pulmonary or hepatic end-stage disease; hepatorenal syndrome; poorly controlled cancer; severe post-anoxic encephalopathy and others)
- •Prior treatment with RRT within 30 days
- •Anticipated alive ICU discharge within 24 hours
- •Readmission to the ICU during the same hospitalization episode.
结局指标
主要结局
28-Days Mortality
时间窗: 1 day
Mortality status of subjects on day 28 from recruitment.
次要结局
- Length of ICU Stay(1 day)
- Length of Ventilator Day(1 day)
研究者
Dr Mohd Shahnaz, MBBS, M Anes
Principal Investigator.
University of Malaya