Pilot Study of Using Multi-parametric Magnetic Resonance Imaging for Organ Delineation and Tumor Response Assessment of Prostate Cancer Patients Being Treated With Radiation Therapy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Prostate Cancer
- Sponsor
- Henry Ford Health System
- Enrollment
- 9
- Locations
- 1
- Primary Endpoint
- Detection of Imaging Biomarkers to Localize the Intraprostatic Lesions and Predict Radiation Treatment Response
- Status
- Terminated
- Last Updated
- 2 years ago
Overview
Brief Summary
This is a pilot study of implement multi-parametric MR imaging for organ delineation and tumor response assessment of prostate cancer patients being treated with radiation therapy.
Detailed Description
The study aims to generate intraprostatic lesions maps based on imaging, perform the treatment planning to compute the highest feasible simultaneous boosting dose to intraprostatic lesion and characterize longitudinal changes in imaging characteristics.
Investigators
Stephen Brown
Director, Radiobiology Research Laboratories
Henry Ford Health System
Eligibility Criteria
Inclusion Criteria
- •Histologically confirmed prostate adenocarcinoma
Exclusion Criteria
- •Patients with metal fragments or implanted devices such as pacemakers and aneurysm clips are not eligible for the study considering
Outcomes
Primary Outcomes
Detection of Imaging Biomarkers to Localize the Intraprostatic Lesions and Predict Radiation Treatment Response
Time Frame: 2 years
Identify the radiomics features selected from multimodal MRI to distinguish the dominant lesions from the normal tissues within the prostate. Track the changes of these features with longitudinal MRI scans to identify its correlation with the local control.
Tumor Response
Time Frame: 2 years
Tumor response as measured by an increase in PSA.