NCT04127500UnknownNot Applicable
The Mechanism of Dexmedetomidine in Improving Delirium After Cardiac Surgery
Nanjing First Hospital, Nanjing Medical University1 site in 1 country200 target enrollmentStarted: August 1, 2019Last updated:
Conditions
Interventions
Drugs
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- α7nAChR level
Study Overview
Brief Summary
The investigators aim to evaluate the roles of α7nAchR in the mechanisms of dexmedetomidine in improving delirium after cardiac surgery. The results of this study would lay the foundation for revealing the mechanisms of dexmedetomidine improving delirium after cardiac surgery and provide a new idea to the early treatment of delirium.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Care Provider)
Eligibility Criteria
- Ages
- 60 Years to 100 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •ICU patients underwent cardiac surgery
- •age ≥ 60 years
Exclusion Criteria
- •Preoperative cognitive decline, mental illness,
- •preoperative long-term use of hormone patients,
- •preoperative alcohol dependence,
- •patients with alcohol withdrawal symptoms
Arms & Interventions
DEX group
Experimental
use DEX
Intervention: dexmedetomidine (Drug)
Outcomes
Primary Outcomes
α7nAChR level
Time Frame: 7 days
delirium incidence
Time Frame: 1 month
Secondary Outcomes
- mechanical ventilation time(7 days)
- ICU stay time(1 month)
Investigators
HONG LIANG
Doctor
Nanjing First Hospital, Nanjing Medical University
Study Sites (1)
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