NCT04127500Unknown不适用
The Mechanism of Dexmedetomidine in Improving Delirium After Cardiac Surgery
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- α7nAChR level
研究概览
简要总结
The investigators aim to evaluate the roles of α7nAchR in the mechanisms of dexmedetomidine in improving delirium after cardiac surgery. The results of this study would lay the foundation for revealing the mechanisms of dexmedetomidine improving delirium after cardiac surgery and provide a new idea to the early treatment of delirium.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 60 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ICU patients underwent cardiac surgery
- •age ≥ 60 years
排除标准
- •Preoperative cognitive decline, mental illness,
- •preoperative long-term use of hormone patients,
- •preoperative alcohol dependence,
- •patients with alcohol withdrawal symptoms
研究组 & 干预措施
DEX group
Experimental
use DEX
干预措施: dexmedetomidine (Drug)
结局指标
主要结局
α7nAChR level
时间窗: 7 days
delirium incidence
时间窗: 1 month
次要结局
- mechanical ventilation time(7 days)
- ICU stay time(1 month)
研究者
HONG LIANG
Doctor
Nanjing First Hospital, Nanjing Medical University
研究点 (1)
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