The Mechanism of Dexmedetomidine in Improving Delirium After Cardiac Surgery

Not Applicable

• Conditions: Delirium; Cardiac Surgery; Dexmedetomidine
• Interventions: Drug: dexmedetomidine

• Registration Number: NCT04127500
• Lead Sponsor: Nanjing First Hospital, Nanjing Medical University

Brief Summary

The investigators aim to evaluate the roles of α7nAchR in the mechanisms of dexmedetomidine in improving delirium after cardiac surgery. The results of this study would lay the foundation for revealing the mechanisms of dexmedetomidine improving delirium after cardiac surgery and provide a new idea to the early treatment of delirium.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-08-01
• Status Verified: 2019-10
• Study First Submitted: 2019-10-12
• Study First Submitted QC: 2019-10-12
• Last Update Submitted: 2019-10-12
• Study First Posted: 2019-10-15
• Last Update Posted: 2019-10-15
• Primary Completion: 2020-07-31
• Study Completion: 2020-08-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• ICU patients underwent cardiac surgery
• age ≥ 60 years

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Exclusion Criteria

• Preoperative cognitive decline, mental illness,
• preoperative long-term use of hormone patients,
• preoperative alcohol dependence,
• patients with alcohol withdrawal symptoms

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
DEX group	dexmedetomidine	use DEX

Primary Outcome Measures

Name	Time	Method
α7nAChR level	7 days
delirium incidence	1 month

Secondary Outcome Measures

Name	Time	Method
mechanical ventilation time	7 days
ICU stay time	1 month

Trial Locations

Locations (1)

Nanjing First Hospital; 🇨🇳 Nanjing, Jiangsu, China