Work Package 2 (WP2) - Normothermic Liver Perfusion Vs Cold Storage in Liver Transplants

Not Applicable

Completed

• Conditions: We are studying the effect of using normothermic liver perfusion to preserve the donor liver on the outcomes of liver transplantation. The disease common to all the recipients is end-stage liver failure.; Surgery

• Registration Number: ISRCTN39731134
• Lead Sponsor: niversity of Oxford (UK)

Brief Summary

2018 results in https://www.ncbi.nlm.nih.gov/pubmed/29670285

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-03-27
• Last Update Posted: 19 November 2018
• Study Completion: 2019-01-31

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 260

Inclusion Criteria

Donor Inclusion Criteria:
1. Donors over the age of 16 years.
2. Liver allografts from donation after brain death (DBD), standard and extended criteria donors (SCD, ECD) and donation after circulatory death (DCD) donors.

Recipient Inclusion Criteria:
1. Adult patients (18 years or more)
2. Active on the waiting list for liver transplantation
3. Able to give informed consent.

Exclusion Criteria

Donor Exclusion Criteria:
1. Living donors
2. Liver intended for split transplant
3. Donor age <16 years
4. Liver in which investigator is unwilling to randomise to either arm

Recipient Exclusion Criteria:
1. Age less than 18 years
2. Acute/fulminant liver failure
3. Transplantation of more than one organ (e.g. liver and kidney)
4. Refusal of informed consent
5. Unable to give informed consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified