Electrocardiographic Changes Among Epileptic and Non Epileptic Seizures in Children at Sohag University Hospital

Not yet recruiting

• Conditions: Seizures
• Interventions: Device: ECG

• Registration Number: NCT06045676
• Lead Sponsor: Sohag University

Brief Summary

Epilepsy is a chronic disease triggered by increased impulsiveness of nerve cells in the brain and may require a lifelong treatment. Epilepsy is confirmed by two or more unprovoked seizures in more than 24 hours. Febrile Convulsion is another type of seizure occurring due to fever over 38 °C without a history of convulsion, CNS infection, electrolyte imbalance, metabolic disorder, intoxication, and trauma. Unlike epileptic seizures, there are non-epileptic seizures such as Breath Holding Spells that affect children's behaviors and often look like epileptic seizures.

QT parameters elongation show the danger of dysrhythmia and unexpected sicknesses such as cardiomyopathy, mitral valve prolapse, ischemic coronary illness, and kidney disorders.

Many investigators have reported changes in QT parameters in various diseases such as diabetes mellitus, celiac disease, thalassemia , epilepsy ,Breath holding spells and febrile seizure.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-09
• Study First Submitted: 2023-09-13
• Study First Submitted QC: 2023-09-13
• Study First Posted: 2023-09-21
• Last Update Submitted: 2023-09-24
• Study Start: 2023-09-25
• Last Update Posted: 2023-09-28
• Primary Completion: 2024-09-25
• Study Completion: 2024-09-25

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

• children with drug resistant epilepsy.
• febrile seizures.
• age of 1 year to 12 years.

Exclusion Criteria

• age below 1 year and above 12 years
• children with convulsion secondary cns infection , encephalitis, encephalopathy , toxic and metabolic problem

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Drug Resistant Epilepsy	ECG	Seizures Not Respond to two lines of Anti epileptic Medications
Breath Holding Spells	ECG	children's behaviors look like epileptic seizures due to crying up to a minute followed by losing consciousness
Drug Responsive Epilepsy	ECG	Seizures Respond to one or two lines of Anti epileptic Medications
Febrile Seizures	ECG	type of seizure occurring due to fever over 38 °C without a history of convulsion
Control	ECG	Healthy Children free from any convulsion

Primary Outcome Measures

Name	Time	Method
QT interval	12 months	Distance from the beginning of the Q wave to the end of the T wave at least in eight leads from the standard ECG

Trial Locations

Locations (1)

Sohag university Hospital; 🇪🇬 Sohag, Egypt