Effect of Propofol-Dexmedetomidine in Anesthesia Induction in Patients with Major Depression or Bipolar-Disorder under Electroconvulsive therapy

Phase 3

Recruiting

Conditions: Condition 1: Bipolar disorders. Condition 2: Major depression.
Bipolar disorder
Major depressive disorder, recurrent

Registration Number: IRCT20231009059668N1

Lead Sponsor: Sanandaj University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 82

Inclusion Criteria

Age 18 to 50 years
Patient in class 1 or 2 ASA physical status
Patient diagnosed with major depression or bipolar disorder referred by a psychiatrist

Exclusion Criteria

History of cardiovascular, kidney, liver and lung disease
History of other mental diseases, except major depression or bipolar disorder
History of head trauma
History of cardiovascular surgery
History of allergy to propofol or foods such as eggs or soybeans
Patient under treatment with bupropion and anticonvulsant
The attending physician's lack of consent for the patient's participation in the study

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Seizure duration. Timepoint: The end of the discharge time of the electric shock until the completion of all visible movements in all parts of the body. Method of measurement: Timer (seconds).;Recovery time. Timepoint: From the end of the injection of succinylcholine to the return of breathing and opening the eyes and following the instructions completely correctly by the patients. Method of measurement: Timer (minutes).;Hemodynamic changes (mean arterial pressure, heart rate). Timepoint: Before induction of anesthesia, during discharge of electric shock, 5, 10 and 15 minutes after discharge of electric shock. Method of measurement: Using a portable automatic monitoring (mean arterial pressure in mmHg and heart rate in beats per minute).

Secondary Outcome Measures

Name	Time	Method
Pain. Timepoint: In 5, 10 and 15 minutes after the end of the electric shock discharge and also the recovery time. Method of measurement: Visual Analogue Scale.;Sedation and agitation. Timepoint: In 5, 10 and 15 minutes after the end of the electric shock discharge and also the recovery time. Method of measurement: Sedation-Agitation Scale.