Propolis Effects on Proteinuria and Kidney Function in Patients With Chronic Kidney Disease
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Reducing Proteinuria
研究概览
简要总结
The aim of this study is to determine the impact of Propolis on proteinuria reduction and protection of the glomerular filtration rate in chronic renal failure patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •older than 18 years;
- •less than 90 years;
- •glomerular filtration rate between 25 and 70 ml / min;
- •proteinuria in the urine 24 hours more than 300 mg or protein / creatinina in isolated urine greater than 0.3g / g or microalbuminuria (albumin / creatinine ratio) between 30-300 mg / g.
排除标准
- •Pregnants;
- •Neoplasia carrier;
- •Renal transplant patients;
- •Patients who refuse to participate in the study.
- •Glomerulopathy on Immunosuppression
研究组 & 干预措施
Propolis
Patients will continue to receive standard treatment for their comorbidities, determined by the attending physician. Patients will receive 500 mg / day of the propolis extract in the form of tablets split in two daily doses.
干预措施: Propolis (Drug)
Placebo
Patients will continue to receive standard treatment for their comorbidities, determined by the attending physician. Patients will receive 500 mg / day of the propolis-placebo in the form of tablets split in two daily doses.
干预措施: Placebo (Drug)
结局指标
主要结局
Reducing Proteinuria
时间窗: One year
Reduction from baseline proteinuria.
次要结局
- Protection of the glomerular filtration rate(One year)
研究者
Marcelo Augusto Duarte Silveira
Principal Investigator
University of Sao Paulo General Hospital