Propolis Effects in Patients With Chronic Kidney Disease
- Registration Number
- NCT02766036
- Lead Sponsor
- University of Sao Paulo General Hospital
- Brief Summary
The aim of this study is to determine the impact of Propolis on proteinuria reduction and protection of the glomerular filtration rate in chronic renal failure patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 32
Inclusion Criteria
- older than 18 years;
- less than 90 years;
- glomerular filtration rate between 25 and 70 ml / min;
- proteinuria in the urine 24 hours more than 300 mg or protein / creatinina in isolated urine greater than 0.3g / g or microalbuminuria (albumin / creatinine ratio) between 30-300 mg / g.
Exclusion Criteria
- Pregnants;
- Neoplasia carrier;
- Renal transplant patients;
- Patients who refuse to participate in the study.
- Glomerulopathy on Immunosuppression
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo Patients will continue to receive standard treatment for their comorbidities, determined by the attending physician. Patients will receive 500 mg / day of the propolis-placebo in the form of tablets split in two daily doses. Propolis Propolis Patients will continue to receive standard treatment for their comorbidities, determined by the attending physician. Patients will receive 500 mg / day of the propolis extract in the form of tablets split in two daily doses.
- Primary Outcome Measures
Name Time Method Reducing Proteinuria One year Reduction from baseline proteinuria.
- Secondary Outcome Measures
Name Time Method Protection of the glomerular filtration rate One year Maintaining glomerular filtration rate or inferior reduction to 5 ml per minute per 1.73 m2 of body-surface area from baseline.
Trial Locations
- Locations (1)
University of Sao Paulo General Hospital
🇧🇷Sao Paulo, Brazil