Effect of citrate-phosphate-Dextrose Solution on reperfusion Injury in Coronary Artery Bypass Surgical Patient Undergoing Cardiopulmonary Bypass
- Conditions
- cardiac.Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
- Registration Number
- IRCT201108147325N1
- Lead Sponsor
- Vice Chancellor, Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
Inclusion criteria were; not having another heart attack or another heart surgery at same time; no previous heart surgery; positive history of past severe disease; on-emergency surgery; the absence of high risk surgery; to abandon cases involving one vessel; uncontrolled diabetes; lack of severe left ventricular dysfunction; no MI with Q wave in 6 past weeks; lack of severe lesions of LM (greater than equal to 50%); unstable angina; non-cytotoxic drugs and radiation use; no recent blood transfusion in past month and willingness to participate in the study; Exiting criteria were; the operation of the on pump switch to off pump; addition of other surgery such as surgery aneurysmectomy LV; performed endarterctomy on the involved vessels ;prolonged clamping more than 100 minutes; prolonged pump more than 130 minutes; hemolysis of samples obtained from patients; clotting of samples taken from patients; lack of proper storage and transport of samples at the usual time; less than 5 / 1 cc of blood serum sample size..
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Measurement of cardiac enzymes and inflammatory factors. Timepoint: Oxidative stress markers in 5 stage and cardiac enzymes in 3 stage of surgery measured. Method of measurement: 10 cc of blood was taken in , before the bypass ,before opening the clamping, opening 10 minutes after clamping from the coronary sinus , first day and second day after surgery from venous blood .
- Secondary Outcome Measures
Name Time Method Total serum antioxidant. Timepoint: Before ischemia and after reperfusion. Method of measurement: Total antioxidant capacity in serum using a commercial kit Ltd Randox Laboratories UK, CatNo.NX2332 were measured.