Relationship Between Muscle Mass and Muscle Relaxation Time

Not Applicable

Completed

• Conditions: Anesthesia
• Interventions: Device: Inbody

• Registration Number: NCT02617433
• Lead Sponsor: Go Eun Bae

Brief Summary

Rocuronium block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles. There have been several studies reported positive relationship between muscle mass and amount of neuromuscular junction. The purpose of this study is to find relationship between muscle mass and muscle relaxation time.

Detailed Description

Rocuronium block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles. There have been several studies reported positive relationship between muscle mass and amount of neuromuscular junction. Until now, dose of rocuronium has been judged by patient's weight and height. However, height and weight do not represent exact muscle mass. The purpose of this study is to find relationship between muscle mass and muscle relaxation time. Measurement of muscle mass will be obtained using bioelectrical impedence analysis.

Study Timeline

• Study First Submitted: 2015-11-23
• Study First Submitted QC: 2015-11-25
• Study Start: 2015-12
• Study First Posted: 2015-12-01
• Status Verified: 2016-05
• Primary Completion: 2016-05
• Study Completion: 2016-05
• Last Update Submitted: 2016-05-02
• Last Update Posted: 2016-05-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 42

Inclusion Criteria

• All patient who undergo general anesthesia.
• Male; weight 70-75kg , height 170-175cm
• Female; weight 53-58kg , height 158-163cm

Exclusion Criteria

• Liver and kidney disease
• Any types of muscle disorder.
• Metal materials or pacemaker in body

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Inbody	Inbody	Participant measure muscle mass by bioelectrical impedance analysis (Inbody 720, Seoul, Korea) after fast for eight hours.

Primary Outcome Measures

Name	Time	Method
ratio of result of first stimulus(T1) to result of supramaximal stimulation(T0)	two hours	T1 and T0 is obtained by train of four which is commonly used neuromuscular monitoring device.

Secondary Outcome Measures

Name	Time	Method
completely suppression time of result of first stimulus(T1).	ten minutes	T1 is obtained by train of four which is commonly used neuromuscular monitoring device.

Trial Locations

Locations (1)

Korea university anam hospital; 🇰🇷 Seoul, Korea, Republic of