TO STUDY THE EFFECT OF NEUROMUSCULAR TRANSMISSION MONITORING ON THE REQUIREMENT OF MUSCLE RELAXANT AND RECOVERY IN PATIENTS UNDERGOING GENERAL ANAESTHESIA

Not Applicable

• Conditions: Health Condition 1: O- Medical and Surgical

• Registration Number: CTRI/2021/10/037382
• Lead Sponsor: Dr D Y Patil Hospital and Research Centre

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Patients undergoing general anaesthesia

Patients under ASA I and II

Age between 18 to 60 years.

Patients willing to sign the informed consent voluntarily

Exclusion Criteria

Pregnant females

Patients with cognitive and mental disorders

Patients with any neuromuscular disorders

ASA III and above

Patients with anticipated difficult intubation

Surgery duration of more than 4 hours

Surgeries in which either major blood loss/fluid shifts expected or occurs

Surgeries of Head and neck

Planned for awake extubations

Patient in need of postsurgery intensive care admission

Patient with body mass index >35 kg/m2

Patient with hepatic disease (liver enzyme value >50% normal value)

Patient with renal insufficiency (serum creatinine >1.8 mg/dL)

Patient with history of consumption of drugs known to affect neuromuscular transmission

Any contraindications to neostigmine and/or atropine sulphate

Patient with history of hypersensitivity or allergic to anaesthetic agent given

Difficulty accessing the TOF measuring device in the ulnar nerve.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To study the effect of neuromuscular transmission monitoring (train of four) on the requirement of muscle relaxant and recovery in patients undergoing general anaesthesiaTimepoint: 6 months

Secondary Outcome Measures

Name	Time	Method
1)To determine the total dose of muscle relaxant requirement for intubation <br/ ><br>2)To determine the dose of intra-operative muscle relaxant requirement per hour <br/ ><br>3)To observe the time required for the patient to respond to verbal commands after stopping of all the anaesthesia maintenance drugs <br/ ><br>4)To observe the time required for extubation <br/ ><br>5)To observe for any postoperative residual paralysisTimepoint: 5 hours