The Heart-Brain Study: the missing link in the pathophysiology of vascular cognitive impairment

Completed

• Conditions: vascular cognitive impairment; 10012272; vascular dementia; 10019280; 10003216

• Registration Number: NL-OMON50275
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 750

Inclusion Criteria

Patients with vascular cognitive impairment with MMSE ><= 20, carotid occlusive
disease of heart failure are included. Further inclusion criteria are age 50+
years, able to undergo cognitive testing, independence in daily life.

Exclusion Criteria

Contraindication for magnetic resonance imaging (MRI) testing

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Cognitive functioning as measured by severity of cognitive impairment on the<br /><br>Clinical Dementia Rating Scale, the MMSE, 15 word verbal learing test<br /><br>(15-WVLT), Stroop interference test, Trail making test, digit span test and the<br /><br>Category fluency test. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Structural and functional brain MRI, cerebral perfusion on MRI, daily<br /><br>functioning as measured by the Amsterdam IADL Questionnaire and Disability<br /><br>Assessment of Dementia, symptoms of depression as measured with the 15-item<br /><br>Geriatric Depression Scale, symptoms of apathy as measured with the Starkstein<br /><br>Apathy Scale.</p><br>