Investigation of the Contributions of Platelet Rich Fibrin Combined With Conventional Periodontal Flap on Periodontal Healing
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Chronic Periodontitis
- Sponsor
- Ataturk University
- Enrollment
- 16
- Locations
- 1
- Primary Endpoint
- Levels of IGF-1, VEGF, BMP-2, FGF-2 on Weekly
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Platelet rich fibrin is a second generation platelet concentration which contains various growth factors. The aim of this study is to evaluate the clinical and biochemical efficacy of PRF in subjects of chronic periodontitis in the operation of conventional periodontal flap.
Detailed Description
PRF was developed in 2001 by Choukroun in France, it was the second generation fibrin adhesive, and was used to accelerate the soft and hard tissue healing. Many studies have shown beneficial effects of PRF on osteoconductive filler material in sinus lift operations, treatment of periodontal sulcus defect and treatment of furcation defects. Also PRF contains many growth factors. PRF accelerates periodontal regeneration through the gradually excreted growth factors and contributes to the bone regeneration. In this study, the investigators evaluated the effect of PRF on growth factors and its contribution to periodontal regeneration in subjects with chronic periodontitis.
Investigators
Alper KIZILDAĞ
Health Sciences Institute
Ataturk University
Eligibility Criteria
Inclusion Criteria
- •Patients with CP who had pocket depth ≤ 5 mm and at least two area (grouped as Control and PRF) with horizontal bone loss after Phase I therapy
Exclusion Criteria
- •The subjects excluded in the study had history of systemic disease, were smokers, had allergy to any drug, had need for prophylaxis of antibiotic and had taken antibiotics at least 6 months
Outcomes
Primary Outcomes
Levels of IGF-1, VEGF, BMP-2, FGF-2 on Weekly
Time Frame: 4 weeks
Change from baseline IGF-1, VEGF, BMP-2, FGF-2 levels of GCF at 1 month were measured by periopaper.
Secondary Outcomes
- Alteration of Clinical Attachment Level(6 month)
- Alteration of Periodontal Pocket Depth(6 month)