Applied The Platelet Rich Fibrin in Chronic Periodontitis

Phase 2

Completed

• Conditions: Chronic Periodontitis
• Interventions: Device: Platelet Rich Fibrin; Device: Conventional Flap Surgery

• Registration Number: NCT02594605
• Lead Sponsor: Ataturk University

Brief Summary

Platelet rich fibrin is a second generation platelet concentration which contains various growth factors. The aim of this study is to evaluate the clinical and biochemical efficacy of PRF in subjects of chronic periodontitis in the operation of conventional periodontal flap.

Detailed Description

PRF was developed in 2001 by Choukroun in France, it was the second generation fibrin adhesive, and was used to accelerate the soft and hard tissue healing. Many studies have shown beneficial effects of PRF on osteoconductive filler material in sinus lift operations, treatment of periodontal sulcus defect and treatment of furcation defects. Also PRF contains many growth factors. PRF accelerates periodontal regeneration through the gradually excreted growth factors and contributes to the bone regeneration. In this study, the investigators evaluated the effect of PRF on growth factors and its contribution to periodontal regeneration in subjects with chronic periodontitis.

Study Timeline

• Status Verified: 2012-12
• Study Start: 2012-12
• Primary Completion: 2013-06
• Study Completion: 2013-12
• Study First Submitted: 2015-10-15
• Study First Submitted QC: 2015-11-02
• Study First Posted: 2015-11-03
• Last Update Submitted: 2016-08-26
• Last Update Posted: 2016-08-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Patients with CP who had pocket depth ≤ 5 mm and at least two area (grouped as Control and PRF) with horizontal bone loss after Phase I therapy

Exclusion Criteria

• The subjects excluded in the study had history of systemic disease, were smokers, had allergy to any drug, had need for prophylaxis of antibiotic and had taken antibiotics at least 6 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Platelet Rich Fibrin	Platelet Rich Fibrin	Platelet Rich Fibrin was applied with conventional flap surgery for treatment of periodontal bone loss in test group.
Conventional Flap Surgery	Conventional Flap Surgery	Platelet Rich Fibrin was not applied to control groups. Only conventional flap surgery was applied to control groups.

Primary Outcome Measures

Name	Time	Method
Levels of IGF-1, VEGF, BMP-2, FGF-2 on Weekly	4 weeks	Change from baseline IGF-1, VEGF, BMP-2, FGF-2 levels of GCF at 1 month were measured by periopaper.

Secondary Outcome Measures

Name	Time	Method
Alteration of Clinical Attachment Level	6 month	Change from baseline Clinical Attachment Levels at 6 months were measured with periodontal probe.
Alteration of Periodontal Pocket Depth	6 month	Change from baseline Pocket Depth at 6 months were measured with periodontal probe.

Trial Locations

Locations (1)

Alper KIZILDAĞ; 🇹🇷 Denizli, Turkey