Evaluation Of The Effects Of Advanced Platelet Rich Fibrin And Concenrated Growth Factor Liquids On Dental Implant Osseointegration: A Randomized Controlled Double-Blind Clinical Trial

Uğur Can ÜNLÜGENÇ2 个研究点分布在 1 个国家目标入组 32 人开始时间: 2020年4月10日最近更新: 2021年5月11日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方
入组人数: 32
试验地点: 2
主要终点: Resonance Frequency Analysis-II

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

In this study, concentrated growth factor obtained by centrifuging the patient's own blood and advanced platelet-rich fibrin liquids were applied to the implant cavity and surface. Thus, it was aimed to ensure that the osseointegration process would start earlier by ensuring a faster arrival of growth factor and healing mediators in the region, and thus, the time waited for the osseointegration process and the loading of the superstructure would be shortened.

In this split-mouth study, a total of 32 patients including two separate study groups in different patients and a control group were included. While the CGF liquid was applied to the implant cavities and surfaces prepared in the study group of 16 patients, A-PRF liquid was applied to the study group of the other 16 patients. Conventional implant application was performed in the control groups of both groups. The torque values during the implantation were also recorded, and Resonance Frequency measurements were performed immediately after implantation with the Penguin RFA device and at postoperative weeks 2, 4, 6 and 12.

详细描述

This study was conducted in accordance with the Helsinki declaration on 32 patients who applied to Hatay Mustafa Kemal University Faculty of Dentistry Department of Oral and Maxillofacial Surgery to have dental implants in order to fix their missing teeth. 2 implants with appropriate sizes and diameters were applied to each patient according to the condition of the recipient bone in order to ensure standardization. It was aimed to ensure that the primary stabilization of the implant would not be affected locally by applying implants to the sites with similar bone density. The implants were placed symmetrically to the right and left of the midline by the same physician provided that they were in the same jaw.

Some conditions were required for the inclusion of patients in the study, which were:

Having no systemic disorder,
Not being pregnant or breastfeeding,
Having no smoking habit,
Lack of continuous drug use due to chronic disease,
No infection in the implant site and adjacent teeth,
No previous implant or any augmentation procedure in the implant site,
Adequate bone height and thickness of the implant site,
The patient's acceptance and signing the informed consent form specific to study describing the aim, duration, advantages and possible complications of the study.

Among the inclusion criteria in the study, no distinction was made between men and women, and the patients without these criteria were not included in the study.

This study evaluating the effects of advanced platelet-rich fibrin and concentrated growth factor liquids on dental implant osseointegration was planned as a randomized, clinical controlled and prospective study. A total of 32 patients included in this study were divided into two groups of 16. It was planned to apply 2 implants to each patient and to evaluate each patient as one side as the control and the other as the study group. In other words, while there was a study group and a control group in the CGF group, there was also a study group and a control group in the A-PRF group. In the first group, it was planned to wash the surface of one of the implants to be applied and the inside of the socket where the implant would be placed with the CGF liquid obtained by centrifuging the patient's own blood, and to apply a standard implant procedure without any application to the socket and surface of the other implant to be applied.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Parallel
主要目的: Treatment
盲法: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

盲法说明

The group in which the patients were included was determined by pulling the closed envelope just before the surgery. Test side was determined by tossing a coin after the implant cavities were prepared but before the implants were placed. The examiners who carried out the measurements and analyzes were unaware of the study and the groups.

入排标准

年龄范围: 38 Years 至 58 Years（Adult）
性别: All
接受健康志愿者: 是

入选标准

•- Having no systemic disorder,
•Not being pregnant or breastfeeding,
•Having no smoking habit,
•Lack of continuous drug use due to chronic disease,
•No infection in the implant site and adjacent teeth,
•No previous implant or any augmentation procedure in the implant site,
•Adequate bone height and thickness of the implant site,
•The patient's acceptance and signing the informed consent form specific to our study describing the aim, duration, advantages and possible complications of the study.
•Among the inclusion criteria in the study, no distinction was made between men and women, and the patients without these criteria were not included in the study.

排除标准

未提供