Betablocker Therapy in Pulmonary Arterial Hypertensio

Phase 2

Completed

• Conditions: idiopathische pulmonale hypertensie; high bloodpressure pulmonary vascular system; pulmonary hypertension; 10019280

• Registration Number: NL-OMON34177
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Idiopathic PAH patients
Stable on PAH specific treatment defined
No change in PAH specific treatment in the past 6 months
No change in functional class in the past 6 months
<10 % change in 6 minute walk distance in the past 6 months
Functional class 2 or 3
In sinus rhythm

Exclusion Criteria

History of systemic hypertension, ischaemic heart disease, valvular disease or cardiomyopathy.
Asthma
Use of concomitant medication other than diuretics, acenocoumarol and PAH targeted therapy
History of cardiac arrhythmias or the use of anti-arrhythmic drugs
Sick sinus syndrome
Systolic hypotension < 90 mmHg
AV-block
Clinically relevant sinus-bradycardia

Study & Design

• Study Type: Interventional
• Study Design: Not specified