Does APOE-e4 Predict Delirium and Cognitive Dysfunction After Surgery?
Completed
- Conditions
- DeliriumPostoperative Cognitive Dysfunction
- Registration Number
- NCT00911677
- Lead Sponsor
- Ottawa Hospital Research Institute
- Brief Summary
Patients with the APOE-ε4 genotype are at increased risk of both vascular dementia and peripheral vascular disease. Patients undergoing major vascular surgery are at particularly high risk of delirium and other, more subtle, changes in cognitive function following surgery. The hypothesis of this trial is that the APOE-ε4 genotype is associated with both delirium and postoperative cognitive dysfunction (POCD).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- Age 60 or greater
- Open repair of the abdominal aorta
Exclusion Criteria
- refusal;
- planned endovascular repair;
- emergency surgery;
- previous diagnosis of dementia, Parkinson's disease, or psychiatric illness;
- active alcohol or substance abuse; and
- physical inability to complete neuropsychometric testing.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Delirium as assessed by the Confusion Assessment Method 7 days postoperatively
- Secondary Outcome Measures
Name Time Method POCD as assessed by a battery of 9 neuropsychometric tests 3 months postoperatively
Trial Locations
- Locations (1)
The Ottawa Hospital - Civic Campus
🇨🇦Ottawa, Ontario, Canada
The Ottawa Hospital - Civic Campus🇨🇦Ottawa, Ontario, Canada