NL-OMON43784
Completed
N/A
The neural substrate of cognitive and social-emotional apathy in patients with schizophrenia - The neural substrate of apathy in schizophrenia
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- apathy
- Sponsor
- niversitair Medisch Centrum Groningen
- Enrollment
- 80
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients with schizophrenia (N\=60\)
- •\- At least 18 years of age
- •\- DSM\-IV diagnosis of schizophrenia, or schizoaffective disorder
- •\- High levels of cognitive or social\-emotional apathy
- •\- Absence or low level of apathy
- •\- Patient groups will be matched on age, sex, education, levels of depressive symptoms, levels of D2 dopamine receptor occupancy and handedness
- •\- Written informed consent;Healthy controls (N\=20\)
- •\- At least 18 years of age
- •\- Matched to patients on age, sex, education, levels of depressive symptoms and handedness
- •\- Written informed consent
Exclusion Criteria
- •Patients with schizophrenia (N\=60\)
- •Presence of a substance dependence disorder
- •Presence of a neurological disorder
- •Use of medication that can influence task results (e.g. beta\-blockers, insulin);Healthy controls (N\=20\)
- •Presence of a neurological or psychiatric disorder, in present or past.
- •Use of medication that can influence task results (e.g. psychopharmaca, beta\-blockers, insulin)
- •High levels of apathy (a score of more than 27 on the AES);All subjects (N\=80\):
- •Visual or hearing problems that cannot be corrected
- •Insufficient knowledge of the Dutch language
- •Inability to undergo cognitive testing
Outcomes
Primary Outcomes
Not specified
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