Conventional Ovarian Stimulation vs. Single Injection Stimulation of Corifollitropin Alfa in Oocyte Donor
Phase 4
Completed
- Conditions
- Ovarian Stimulation
- Interventions
- Drug: Time of administration of Corifollitropin Alfa
- Registration Number
- NCT03939403
- Lead Sponsor
- Instituto Bernabeu
- Brief Summary
This study aims to study the efficiency of using a single injection of Corifollitropin alfa for ovarian stimulation by initiating administration late and without further administration of follicle-stimulating hormone after the 7th day of stimulation compared to conventional ovarian stimulation using Corifollitropin alfa (drug administration 5 days after cessation of hormonal contraceptive and supplementation with follicle-stimulating hormone daily administration from the 8th day of stimulation).
This a controlled randomized clinical study and 180 patients will be recruited (90 per arm) and the primary study outcome is the number of obtained oocytes.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 180
Inclusion Criteria
- Eligible for oocyte donation program
- Age between 18 and 32 years old
- BMI >18 and <30
- Antral follicle count >12 (summing both ovaries)
- Presence of both ovaries
- Ability to participate in and comply with study protocol
- Signed informed consent
- No treatment with ovulation stimulators in the 3 months prior to the start of stimulation.
Exclusion Criteria
- Diagnosis of endometriosis at any stage
- AFC >20
- Polycystic ovary syndrome
- Concurrent participation in another study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 7-days pill free interval Time of administration of Corifollitropin Alfa -
- Primary Outcome Measures
Name Time Method Number of oocytes At the end of stimulation Number of oocytes after stimulation
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Instituto Bernabeu
🇪🇸Alicante, Spain