VOCs in Patients With Acute Cardiogenic Chest Pain

Not Applicable

Recruiting

• Conditions: Acute Coronary Syndrome; Acute Aortic Syndrome
• Interventions: Diagnostic Test: VOCs

• Registration Number: NCT06277895
• Lead Sponsor: Qilu Hospital of Shandong University

Brief Summary

The goal of this observation study is to compare VOCs in cardiogenic chest pain population/health conditions, to answer：Establishment and promotion of the application system of emergency rapid detection of expiratory Volatile Organic Compounds (VOCs) in patients with acute cardiogenic chest pain

1. VOCs levels were measured at baseline in healthy people, and markers of VOCs that could be used to identify acute cardiogenic chest pain were sought.

2. The relationship between abnormal VOCs (mainly aldehydes) and prognosis of patients and the correlation with Super-score for early warning of acute heart failure.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-01
• Study First Submitted: 2024-01-25
• Study Start: 2024-01-26
• Study First Submitted QC: 2024-02-18
• Last Update Submitted: 2024-02-18
• Study First Posted: 2024-02-26
• Last Update Posted: 2024-02-26
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1400

Inclusion Criteria

Observation group inclusion criteria:

1. Over 18 years old, male or female;
2. Patients with acute cardiogenic chest pain (see diagnostic criteria);
3. Patient's informed consent.

Inclusion criteria of healthy control group:

1. Over 18 years old, male or female;
2. Centerless cerebrovascular disease, lung disease, no abnormal liver and kidney function, no acute infection recently;
3. Informed consent.

Exclusion Criteria

1. The patient had difficulty in collecting breath;
2. Patients with terminal illness or receiving palliative care;
3. Have participated in other clinical studies or consider it inappropriate to participate in this study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
normal group	VOCs	Healthy population
cardiogenic chest pain group	VOCs	cardiogenic chest pain group/acute coronary syndrome

Primary Outcome Measures

Name	Time	Method
Baseline VOCs (aldehydes) levels in healthy population	Baseline	Baseline VOCs (aldehydes) levels in healthy population

Secondary Outcome Measures

Name	Time	Method
MACE in patients with cardiogenic chest pain	From enrollment to the end of treatment at 30 days	the relationship between the different VOCs levels and 30-day MACE in patients with cardiogenic chest pain

Trial Locations

Locations (1)

Qilu hospital; 🇨🇳 Jinan, Shandong, China