Sympatholytic Effects of High Thoracic Erector Spinae Plane Block: A Prospective Observational Study on Changes in Optic Nerve Sheath Diameter
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 15
- 主要终点
- Optic nerve sheath diameter (ONSD)
研究概览
简要总结
The thoracic erector spinae plane (ESP) block is suggested to potentially affect the stellate ganglion, a key component of the sympathetic nervous system, thereby influencing autonomic functions. Changes in optic nerve sheath diameter (ONSD) are used as indicators of intracranial pressure changes. This study aims to investigate the effects of the ESP block on ONSD, providing insights into its impact on the stellate ganglion and enhancing the understanding of the ESP block's safety and efficacy.
详细描述
The thoracic erector spinae plane (ESP) block is a regional anesthesia technique. This technique involves the injection of local anesthetics into the deep layers of the erector spinae muscles, blocking both somatic and visceral pain pathways. Although various studies have been conducted on the effectiveness of this technique in different clinical situations over the years, further research is needed to understand the precise mechanisms behind its neuroanatomical effects.
The stellate ganglion, an important component of the sympathetic nervous system, plays a crucial role in the regulation of several autonomic functions. It has been suggested that the ESP block may affect the stellate ganglion through its injection at the upper thoracic levels. Changes in the optic nerve sheath diameter (ONSD) have been used as an important indicator of intracranial pressure changes. Any potential changes in ONSD following stellate ganglion blockade could help elucidate the effects of the ESP block, thus aiding in the understanding of its safety and potential benefits for analgesia.
The aim of this study is to investigate the changes in optic nerve sheath diameter in patients undergoing the thoracic ESP block, which could provide more information on the impact of the ESP block on the stellate ganglion. By doing so, we aim to gain further insights into the potential analgesic effects and safety of the ESP block.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults with neck, shoulder, and arm pain
- •Those with complex regional pain syndrome
- •The study will include 15 adult patients who are planned to receive T2-ESP block treatment.
- •Age between 18-65 years
- •Both genders
- •ASA physical status I-II
排除标准
- •Those who refuse procedures and tests
- •Individuals with conditions that can increase intracranial pressure
- •Those with severe heart failure
- •Individuals with second or third-degree atrioventricular block
- •Those with a history of unstable angina
- •Individuals with COPD or chronic asthma
- •Those who have experienced a myocardial infarction (MI) within the last 6 weeks
- •Individuals with a heart rate below 50 beats per minute
- •Those with systolic blood pressure below 90 mmHg
- •Individuals with liver failure
- •Those with kidney failure
- •Individuals for whom a supraclavicular block is anatomically impossible
- •Those with neurological or psychological conditions that complicate test evaluation
- •Individuals allergic to any of the study medications
- •Pregnant individuals
结局指标
主要结局
Optic nerve sheath diameter (ONSD)
时间窗: Before the block and 30 minutes after the block.
To investigate the change in optic nerve sheath diameter (ONSD) following the thoracic erector spinae plane (ESP) block.
次要结局
- Pain relief Visual Analog Scale (VAS)(Pain levels will be assessed using the VAS before the block, 30 minutes after the block, and 24 hours later to evaluate the effectiveness of the intervention.)
- Monitoring of Perfusion Index (PI)(All perfusion index (PI) values will be measured at 3-minute intervals using 2 pulse oximeter sensors on both the blocked and contralateral unblocked upper extremities up to 30 minutes after local anesthetic injection.)
研究者
ismet çopur
principal investigator
Pamukkale University
