ISRCTN84743489已完成4 期
Cardiovascular and functional consequences of chronic kidney disease in older people: a single centre non-randomised interventional treatment trial
Derby Hospital NHS Foundation Trust (UK)0 个研究点目标入组 80 人开始时间: 2010年5月19日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Aged greater than 70 years
- •2. CKD 3, 4 or hypertensive (greater than 130/80) with no renal disease
排除标准
- •1. Use of more than 3 drugs for blood pressure control
- •2. Likely to develop CKD 5 within one year
- •3. Poor mobility precluding completion of assessment
- •4. Diabetes
- •5. Abbreviated mental test (AMT) score < 8
- •6. Recent acute illness (within 3 months)
- •7. Ischaemic heart disease requiring beta-blockade (nitrates/nicorandil are permitted)
- •8. Involvement in another clinical trial within 3 months
- •9. Attending day hospital or attending falls reduction services
- •10. Residents in nursing or residential homes
- •11. Renovascular disease precluding ACE-inhibitor (ACEi) or Angiotensin Receptor Blocker (ARB) usage
- •12. BP prior to antihypertensive withdrawal > 160/90mmHg
- •13. Malignant hypertension
- •14. Severe peripheral vascular disease or significant valvular heart disease
- •15. Heart failure (NYHA III/IV) or other cause to prevent diuretic withdrawal
- •16. Atrial fibrillation or other significant arrhythmia (precludes pulse wave velocity (PWV) measurement)
- •17. Currently taking antihypertensive medication for which MRHA approval (CTA) has not been granted
- •18. Active Obstructive uropathy
研究者
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