High-resolution ultrasonography of peripheral nerves in neurofibromatosis

Completed

• Conditions: Neurofibromatosis; von Recklinghausen disease; 10034606

• Registration Number: NL-OMON44058
• Lead Sponsor: Sint Elisabeth Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

- Confirmed neurofibromatosis type 1 or type 2
- Age between 18 years and 80 years

Exclusion Criteria

- Physical inability to conduct ultrasound or electrodiagnostics (eg. due to cast, recent operation, reconstructive surgery on extremities)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>High resolution ultrasonography (HRUS) of the peripheral nerves will be<br /><br>performed according to a HRUS protocol. A 7-18MHz transducer will be used<br /><br>during all examinations. Every nerve will be judged on size, echogenicity and<br /><br>vascularity. Images of the peripheral nerves at anatomical landmarks, or<br /><br>abnormalities will be saved in order to be reviewed at a later stage.<br /><br>Sonography data and abnormalities will be used as primary outcome measure.<br /><br><br /><br>Follow-up 1 year:<br /><br>Sonography will be performed again after 1 year with use of the same protocol.<br /><br>primary outcome is the development of sonographic abnormalities over time.</p><br>