The Impact of High Intensity Exercise Upon EPC Number and Function in Young Women

Not Applicable

• Conditions: Exercise Anaphylaxis
• Interventions: Behavioral: Sprint interval exercise; Behavioral: Maximal continuous exercise

• Registration Number: NCT01314573
• Lead Sponsor: University of Leeds

Brief Summary

The purpose of the study is to examine the effects of different exercise intensity training programs upon blood vessel function and circulating blood cells involved in blood vessel repair in young women. The long term effects of exercise may be beneficial to cardiovascular health and it is important to understand the training methods that are the most beneficial. In particular we aim to determine if brief maximal exercise improves the function and stiffness of blood vessels and enhance blood vessel repair. Two methods of exercising are being compared, exercise bouts involving intermittent exercise and exercise completed all at once, but at a very high intensity.

Detailed Description

Not available

Study Timeline

• Status Verified: 2011-03
• Study Start: 2011-03
• Study First Submitted: 2011-03-11
• Study First Submitted QC: 2011-03-11
• Last Update Submitted: 2011-03-11
• Study First Posted: 2011-03-14
• Last Update Posted: 2011-03-14
• Primary Completion: 2012-09
• Study Completion: 2012-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 12

Inclusion Criteria

• Young healthy females
• Between 18-25 years old
• No on medication (this includes contraceptives)

Exclusion Criteria

• Medication use (including oral contraceptives)
• Amenorrhoea
• High blood pressure
• Very active (>3 hours per week of organized physical activity)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Interval maximal exercise	Sprint interval exercise	Interval exercise involving repeated Wingate tests (30s durations of maximal exercise on a cycle ergometer).
Continuous maximal exercise	Maximal continuous exercise	Continuous exercise of maximal exertion that has been work matched to an initial bout of interval exercise of 4 x 30s of maximal exercise. This exercise is performed on a cycle ergometer.

Primary Outcome Measures

Name	Time	Method
Maximal oxygen uptake	4 weeks	A measure of aerobic capacity determined during an incremental exercise test to volitional fatigue on an exercise ergometer.

Secondary Outcome Measures

Name	Time	Method
Circulating angiogenic cell numbers	4 weeks	These cells are involved in vascular repair and proliferation and may be measured using flow cytometric methods. Specifically cells with CD34 and CD309 antigens are enumerated.
Heart rate variability	4 weeks
Arterial stiffness	4 weeks	The stiffness of the carotid artery is measured using a combination of ultrasound imaging and non-invasive blood pressure measurements. Lower degrees of stiffness are more favourable.
Flow mediated dialtion	4 weeks	Measure of vascular endothelial function determined non-invasively at the brachial artery
Endothelial progenitor cell function	4 weeks	Measure of in vitro migratory, adhesion and classification of endothelial progenitor cells.

Trial Locations

Locations (1)

University of Leeds; 🇬🇧 Leeds, West Yorkshire, United Kingdom