A randomised study to compare the outcomes after realignment knee surgery versus non-surgical treatment with bespoke knee physiotherapy, for patients under 60 years of age with osteoarthritis of the knee

Not Applicable

• Conditions: Medial compartment knee osteoarthritis; Musculoskeletal Diseases

• Registration Number: ISRCTN99042491
• Lead Sponsor: niversity of Edinburgh

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-01-25
• Last Update Posted: 3 October 2023
• Study Completion: 2027-07-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 224

Inclusion Criteria

1. Patient aged <60 years old with symptomatic medial compartment knee OA who the treating orthopaedic surgeon considers a suitable candidate for medial opening wedge HTO

Exclusion Criteria

1. Aged <18 or >60 years old
2. Body mass index (BMI) >40
3. Patients considered for HTO but who DO NOT have any knee OA including:
3.1. Offloading HTO for concomitant cartilage repair (No OA)
3.2. Offloading HTO solely to treat ligamentous instability (ACL/PCL)
3.3. Symptomatic avascular necrosis/osteonecrosis
3.4. Correction of intraarticular or extraarticular post-traumatic knee deformity
4. Patients requiring double-level knee osteotomy for correction of deformity
5. History of inflammatory arthropathy including rheumatoid arthritis, gout, psoriasis
6. Previous high tibial or distal femoral osteotomy in the same or contralateral knee
7. Previous knee replacement (partial or total) in the same or contralateral knee
8. Cognitive impairment or inability to consent.
9. Inability to comply with study procedures.
10. Previous history of septic arthritis in the knee

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Patients' opinions about their knee and associated problems measured using the patient-reported Knee Injury and Osteoarthritis Outcome Score (KOOS) at 24 months