Silver Diamine Flouride in Arresting Enamel Caries
- Registration Number
- NCT07125937
- Lead Sponsor
- HITEC-Institute of Medical Sciences
- Brief Summary
This interventional study aims to evaluate the effectiveness of 38% Silver Diamine Fluoride (SDF) in arresting enamel caries in adults aged 18-50 years. Dental caries is a biofilm-mediated, multifactorial disease that can cause progressive tooth damage. Conventional treatments are invasive and costly, whereas SDF offers a non-invasive, low-cost alternative. A total of 250 patients meeting the inclusion criteria will be treated with SDF following the UCSF protocol. Lesions will be evaluated clinically using ICDAS and radiographically using ICCMS at 3 weeks and 3 months post-intervention. The primary outcome is the proportion of enamel caries lesions arrested after treatment. Data will be analyzed using the chi-square test.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 250
- Age group of subjects between 18 - 50 years
Carious lesions with ICDAS score 1, 2 and 3 in molars and premolars
- PDL widening with periapical radiolucency around molars and premolars
Premolars and Molars with any white lesions other than caries
Third molars
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 38% Silver Diamine Fluoride Application 38% Silver Diamine Fluoride Participants will receive a single application of 38% Silver Diamine Fluoride (Advantage Arrest™, Elevate Oral Care LLC) on enamel caries lesions (ICDAS scores 1-3) in molars and premolars, following the UCSF protocol. Lesions will be evaluated clinically (ICDAS) and radiographically (ICCMS) at 3 weeks and 3 months post-treatment to assess caries arrest.
- Primary Outcome Measures
Name Time Method Proportion of enamel caries lesions arrested after SDF application 3 months post-intervention Lesions will be clinically evaluated using the International Caries Detection and Assessment System (ICDAS) and radiographically using the International Caries Classification and Management System (ICCMS). Arrest is defined as no progression in ICDAS score and no radiographic progression
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hitec Ims
🇵🇰Rawalpindi, Punjab, Pakistan
Hitec Ims🇵🇰Rawalpindi, Punjab, Pakistan