Silver

Overview

Silver (Ag) is a chemical element that belongs in the family of transition metals in the periodic table. It has a high electrical conductivity, thermal conductivity, and reflectivity. Silver exists as a pure elemental form, alloy with other metals, and mineral. Having critical roles in various applications inducing chemical and industrial fields, silver compounds have also been used in the field of medicine for centuries due to their broad-spectrum biological actions. Silver nanoparticles especially have been widely used in industrial, household, and healthcare-related products due to their potent antimicrobial activity. Silver nitrate and Silver sulfadiazine have been used as topical antibacterial agents for the treatment of skin infections, while Silver sulfadiazine has also been valued for topical burn treatment . Silver and its compounds have been used in trials studying the management of dental caries since the 1800s, and they may be found in dental pastes as an active ingredients. However, some drawbacks of dental use of silver compounds include tooth discolouration and pulp irritation .

Indication

Indicated for the treatment of acne for topical use or the management of dental caries for dental use.

Associated Conditions

Acne

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Preventive Effects of Silver Diamine Fluoride on Early Enamel Caries	2025/01/29	NCT06797882	Phase 2	Not yet recruiting	National University of Malaysia
Effect of Silver Diamine Fluoride Application on Oral Microbiome of Healthy Pediatric Patient	2024/11/21	NCT06699199	Phase 4	Recruiting	King Abdulaziz University
Silver Nitrate Vs. Triamcinolone for Treatment of Hypergranulation Tissue	2024/11/08	NCT06681194	Phase 2	Not yet recruiting	Francesco Egro
The Desensitising Effect of Nanosilver Fluoride in Molar-Incisor Hypomineralisation	2024/04/05	NCT06348849	Phase 2	Completed	Alexandria University
The Anticariogenic Effect of Silver Diamine Fluoride and Sodium Fluoride Varnish	2024/03/18	NCT06316323	Phase 1	Completed	Universiti Teknologi Mara
Clinical Effectiveness and Parental Acceptance of Silver Diamine Fluoride in Preschool Children: A Non-randomized Trial	2024/03/05	NCT06293547	Not Applicable	Completed	Cumhuriyet University
Arresting Early Childhood Caries With a Silver Diamine Fluoride Gel	2024/02/05	NCT06241261	Phase 2	Recruiting	The University of Hong Kong
Evaluation of Antimicrobial Efficacy and Postoperative Pain After Using Silver Nanoparticles and Chitosan Nanoparticles Against Enterococcus Faecalis and Candida Albicans Biofilm	2023/12/15	NCT06172023	Not Applicable	Completed	Minia University
Nutritional Optimization and Bone Health Management for Older Adults Undergoing Hip Fracture Surgery	2023/08/02	NCT05971173	Early Phase 1	Active, not recruiting	The University of Texas Health Science Center at San Antonio
Comparison of Cariostatic Effect of Nano-Silver Fluoride Versus Silver Diamine Fluoride	2023/07/12	NCT05941429	Phase 1	Active, not recruiting	Cairo University

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
Sovereign Silver First Aid Gel Topical Healing Homeopathic Medicine	Natural Immunogenics Corp.dba SOVEREIGN NATURALS	52166-020	TOPICAL	30 [hp_X] in 1 mL	5/22/2025
Argentyn 23Professionele Eer Professionele Eerste Hulp Zilver Gel	Natural Immunogenics Corp.dba SOVEREIGN NATURALS	52166-009	TOPICAL	23 mg in 1000 mL	5/22/2025
Sovereign Silver Eerste Hulp Gel	Natural Immunogenics Corp.dba SOVEREIGN NATURALS	52166-012	TOPICAL	23 mg in 1000 mL	5/22/2025
Sovereign Silver Eerste Hulp Gel	Natural Immunogenics Corp.dba SOVEREIGN NATURALS	52166-011	TOPICAL	23 mg in 1000 mL	5/22/2025
SOVEREIGN SILVER NATURAL HEALING SKIN CARE	Natural Immunogenics Corp.dba SOVEREIGN NATURALS	52166-026	TOPICAL	30 [hp_X] in 1 mL	5/22/2025
Argentyn 23 Professionele Eerste Hulp Zilver Gel	Natural Immunogenics Corp.dba SOVEREIGN NATURALS	52166-010	TOPICAL	23 mg in 1000 mL	5/22/2025
SOVEREIGN SILVER NATURAL HEALING SKIN CARE	Natural Immunogenics Corp.dba SOVEREIGN NATURALS	52166-025	TOPICAL	30 [hp_X] in 1 mL	5/22/2025
SOVEREIGN SILVER FIRST AID HOMEOPATHIC MEDICINE	Natural Immunogenics Corp.dba SOVEREIGN NATURALS	52166-018	TOPICAL	30 [hp_X] in 1 mL	5/22/2025
Metox	Deseret Biologicals, Inc.	43742-1312	ORAL	12 [hp_X] in 1 mL	5/27/2025
Argentyn 23	Natural Immunogenics Corp.dba SOVEREIGN NATURALS	52166-001	TOPICAL	30 [hp_X] in 1 mL	5/22/2025

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
No HSA approvals found for this drug.

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
SILVER HEALTH - COLLOIDAL SILVER 30 PPM	336070	Silver Health	Medicine	A	5/9/2020
Silverwell Colloidal Silver Gel.	318342	Silver Well Colloidal Silver	Medicine	A	6/4/2019

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
LIQUID SILVER	nature's sunshine products of canada ltd.	02243420	Liquid - Oral	3 X	2/6/2001
UNDA 44	seroyal international inc.	02236592	Pellet , Granules , Tablet , Drops , Liquid - Oral	12 X	4/6/1998
ARGENTUM METALLICUM - LIQ 3X	pharmaceutical laboratories inc.	02219778	Liquid - Oral	3 X / ML	7/30/1997
UNDA 46	seroyal international inc.	02233262	Liquid , Drops , Granules , Pellet , Tablet - Oral	12 X	4/6/1998
UNDA 26	seroyal international inc.	02233245	Granules , Drops , Tablet , Pellet , Liquid - Oral	12 X	4/6/1998
UNDA 22	seroyal international inc.	02233237	Pellet , Tablet , Drops , Granules , Liquid - Oral	12 X	4/6/1998
TAM COMP	weleda ag heilmittelbetriebe	02175002	Powder - Oral	3 D / D	4/9/1998
ARGENT COLLOIDAL SOLUTE 6DH	dolisos laboratoires s.a.	00727970	Drops - Oral	4 X / X	12/31/1987
ARGENTUM ONT 2D	weleda ag heilmittelbetriebe	00887838	Ointment - Topical	2 D / D	4/7/1998
ARGENTUM METALLICUM 3X (6X)	silcol	02243438	Drops - Oral	3 X	7/1/2002

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
No CIMA AEMPS (Spain) approvals found for this drug.

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

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