Imaging genetics in Autism Spectrum Disorders

Completed

• Conditions: autism ASD; 10037173

• Registration Number: NL-OMON35266
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 600

Inclusion Criteria

General Inclusion criteria
1) Aged at least 6 years ;Inclusion criteria for subjects with ASD
1) DSM-IV (APA, 1994) diagnosis in the autism spectrum;Inclusion criteria for controls
1) no DSM-IV (APA, 1994) diagnosis
2) no scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)
3) IQ > 70

Exclusion Criteria

1) major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system
2) presence of metal objects in or around the body (pacemaker, dental braces)
3) history of or present neurological disorder
4) for individuals over 12 years of age: legal incompetence, defined as the obvious inability to comprehend the information that is presented by the investigator and is outlined in the Information letter and on which the decision to participate in the study is to be based

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome measures will be genotype on autism risk genes and measures<br /><br>of brain structure, such as volume, gray and white matter density and white<br /><br>matter integrity. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcome measures will be the results form questionnaires, interview<br /><br>and psychological assessment. </p><br>