ST-Segment Resolution as a Marker for Myocardial Scar in ST-Segment Elevation Myocardial Infarction

Completed

• Conditions: Cardiovascular Diseases
• Interventions: Diagnostic Test: ST-segment resolution <40.15%

• Registration Number: NCT04586582
• Lead Sponsor: Chongqing Medical University

Brief Summary

Clinical studies found that poor ST-segment resolution (STR) in electrocardiogram (ECG) occurred in major adverse cardiovascular events (MACE), arrhythmia and heart failure was significantly higher . In clinical work, in patients have poor ST-segment decline, the investigators found by CMR-LGE the corresponding myocardium become thinner and other signs of myocardial scar.

The investigators aimed to establish whether poor ST-segment resolution in ECG, as well as CMR-LGE, could detect the presence of myocardial scar in early STEMI patients. In order to provide convenient, cheap and widely used test method for patients who cannot tolerate CMR-LGE.

42 STEMI patients with single-branch coronary artery stenosis or occlusion were enrolled. ST-segment elevations were measured on the baseline and 24 hours after PCI. The study population was divided into two groups by late gadolinium enhanced cardiac magnetic resonance (LGE- CMR), with transmural myocardial scar (\>75%) or non-transmural myocardial scar (\<75%).

Detailed Description

Not available

Study Timeline

• Study Start: 2017-07-01
• Primary Completion: 2018-12-30
• Study Completion: 2019-04-30
• Status Verified: 2020-10
• Study First Submitted: 2020-10-02
• Study First Submitted QC: 2020-10-07
• Last Update Submitted: 2020-10-07
• Study First Posted: 2020-10-14
• Last Update Posted: 2020-10-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

1. Single-branch coronary artery stenosis or occlusion
2. Restoration of coronary perfusion to TIMI flow grade 3 after PCI

Exclusion Criteria

1. A prior history of the acute coronary syndrome
2. Coronary revascularization
3. Severe chronic kidney disease
4. Intracardiac pacing leads or other implants precluding CMR-LGE
5. Hemodynamic instability
6. Known claustrophobia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
ST-segment resolution <40.15%	ST-segment resolution <40.15%	ST-segment resolution \<40.15%
ST-segment resolution >40.15%	ST-segment resolution <40.15%	ST-segment resolution \>40.15%

Primary Outcome Measures

Name	Time	Method
ST-segment resolution<40.15%	1) Emergency admission: ST-segment elevations were measured. 2) 24 hours after PCI: ST-segment elevations were measured. 3) 7 days after PCI: CMR-LGE was performed.	CMR-LGE was performed to evaluate myocardial scars.
ST-segment resolution>40.15%	1) Emergency admission: ST-segment elevations were measured. 2) 24 hours after PCI: ST-segment elevations were measured. 3) 7 days after PCI: CMR-LGE was performed.	CMR-LGE was performed to evaluate myocardial scars.

Trial Locations

Locations (1)

The first affiliated hospital of Chongqing medical university; 🇨🇳 Chongqing, Chongqing, China