The Metabolic Road to Diastolic Heart Failure (MEDIA) - Diastolic Heart Failure Study (DHF) - MEDIA-DHF-study

Vrije Universiteit Medisch Centrum0 个研究点目标入组 225 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•Patients 18 years of age or older
•Able and willing to provide freely given written informed consent including analysis of genomics.
•Signs or symptoms of Heart Failure, preserved LVEF (>50%) and evidence of diastolic dysfunction: ;The ratio of early mitral valve flow velocity (E) and early TD lengthening velocity (E*), E/E*>15.
•In the case that E/E* ratio is only suggestive of diastolic LV dysfunction (15>E/E*>8), additional non-invasive measures are required for the diagnosis of LV diastolic dysfunction. These consist of:
•Plasma levels of natriuretic peptides (NT-proBNP> 220 pg/mL or BNP > 200 pg/mL) OR
•Echo - blood flow Doppler of mitral valve - ratio of early (E) to late (A) mitral valve flow velocity (E/A) <0.5 and deceleration time (DC) > 280 ms OR
•Echo- blood flow Doppler of pulmonary veins - duration of reverse pulmonary vein atrial systole flow (Ard) and duration of mitral valve atrial wave flow (Ad) (Ard-Ad >30ms) OF
•Echo measure of left atrial volume index (LAVI) > 34 mL/m2 OR
•Echo measure of left ventricular max index (LVMI)> 109 g/m2 for women; 132 g/m2 for men) OR
•Electrocardiografic evidence of atrial fibrillation

•Patients with acute myocardial infarction
•Recent trauma or surgery (< 3 months)
•Hemodynamically significant valvular disease
•Serious cerebrovascular disease or stroke in the last 3 months
•Chronic dialysis
•Chronic liver disease
•Chronic infectious (bacterial or viral) disease
•Any malignant concomitant diseases or a malignant disease in the last 5 years
•Systemic inflammatory diseases, such as autoimmune diseases, connective tissue diseases or collagenoses
•Pregnant women

发起方