Fluoxetine vs. Brief Psychotherapy in the Treatment of Major Depression - a Randomized Comparative Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 85
- 主要终点
- HAM-D
研究概览
简要总结
In this study we compare two treatments for major depression - fluoxetine and brief psychodynamic psychotherapy. In addition to more traditional outcome measures, we also measure the densities of 5HT-1A and D-2 receptors before and after the treatment. The main hypothesis is that brief psychotherapy is as effective as fluoxetine.
详细描述
This study is a randomized comparison of two treatments for major depression - fluoxetine and brief psychodynamic psychotherapy. The patients are recruited from occupational health services and suffer from mild to moderate major depressive disorder. The treatments last for 16 weeks. The main outcome measures include HAM-D, BDI, SOFAS, Rand-36. In addition to more traditional outcome measures, we also measure the densities of 5HT-1A and D-2 receptors before and after the treatment using Positron Emission Tomography (PET) . The main hypothesis is that brief psychotherapy is as effective as fluoxetine, but differences between the treatments are seen in PET scanning.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •MDD (mild to moderate)
- •HDRS 15 or more, age 20-60 years
- •No treatment for preceding 4 months
- •No DSM-IV axis I or II comorbidity
- •No severe somatic illness
- •No contraindications for fluoxetine treatment
排除标准
- 未提供
研究组 & 干预措施
2
Short-term psychodynamic psychotherapy
干预措施: Short-term psychodynamic psychotherapy (Behavioral)
1
Fluoxetine
干预措施: Fluoxetine (Drug)
结局指标
主要结局
HAM-D
时间窗: 0, 16 weeks, one year
次要结局
未报告次要终点