The Role of Antidepressants or Antipsychotics in Preventing Psychosis

St. Luke's-Roosevelt Hospital Center0 sitesOctober 2012

ConditionsPsychotic Disorder

InterventionsAntidepressant Antipsychotic

DrugsAntidepressant Antipsychotic

Overview

Phase: Not Applicable
Intervention: Antidepressant
Conditions: Psychotic Disorder
Sponsor: St. Luke's-Roosevelt Hospital Center
Primary Endpoint: Attenuated positive, negative and general psychiatric symptoms
Status: Withdrawn
Last Updated: 11 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Similar Trials

Overview

Brief Summary

This is a randomized, controlled pilot study comparing the antidepressant fluoxetine with the second generation antipsychotic aripiprazole in approximately 10 subjects aged 12-25 at risk for developing psychosis.

Our primary hypotheses are that compared to aripiprazole, fluoxetine will be better tolerated and will lead to greater improvement in symptoms at the end of 6 months of treatment.

Registry

clinicaltrials.gov

Start Date

October 2012

End Date

May 2014

Last Updated

11 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

St. Luke's-Roosevelt Hospital Center

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•12-25 years of age (inclusive)
•Able to understand and speak English
•Have at least one sub-threshold positive psychotic symptom that is moderate, moderately severe, or severe

Exclusion Criteria

•Lifetime diagnosis of an Axis I psychotic disorder: schizophreniform disorder; schizophrenia; schizoaffective disorder; bipolar disorder; or major depression with psychotic features
•Current psychosis
•Current diagnosis of Major Depressive Disorder, single episode or recurrent, severe without psychotic features
•Lifetime diagnosis of substance abuse or dependence (excluding nicotine)
•Current stimulant treatment
•Any significant medical condition that contra-indicates treatment with either aripiprazole or fluoxetine, including history of neurological, neuroendocrine or other medical condition known to affect the brain
•Estimated intelligence quotient \< 70