Study of the Occurrence of Cardiocirculatory Arrest as a Function of the Level of Hypoxemia During a Maastricht 3 Procedure

Not yet recruiting

• Conditions: Cardiac Arrest; Reanimation

• Registration Number: NCT06780722
• Lead Sponsor: Nantes University Hospital

Brief Summary

Evaluation of the level of hypoxemia during the occurrence of cardiocirculatory arrest during a Maastricht III organ donation procedure.

Detailed Description

Evaluation of the level of hypoxemia during the occurrence of cardiocirculatory arrest during a Maastricht III organ donation procedure.

Study Timeline

• Status Verified: 2025-01
• Study First Submitted: 2025-01-13
• Study First Submitted QC: 2025-01-13
• Study First Posted: 2025-01-17
• Last Update Submitted: 2025-01-17
• Last Update Posted: 2025-01-20
• Study Start: 2025-06-01
• Primary Completion: 2026-12-31
• Study Completion: 2027-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
PaO2 level	24 hours	PaO2 level and its 95% confidence interval in the event of circulatory cardiac arrest, defined as no electrical activity and a pulse pressure below 5 mmHg, during a Maastricht III procedure.

Secondary Outcome Measures

Name	Time	Method
Spo2 Level	24 hours	Define the level of Spo2 (and its 95% confidence interval) at the time of cardiocirculatory arrest during a Maastricht III procedure.
Time between occurrence of first episode of pulsed oxygen saturation below 95% and onset of cardiocirculatory arrest	24 hours	Define the time (and its 95% confidence interval) between the occurrence of the first first episode of pulsed oxygen saturation below 95% and the onset of cardio-circulatory arrest defined by absence of electrical activity and pulsed pressure below 5 mmHg.
Correlation between the rate of delayed recovery of renal function in the recipient and the presence of hypoxemia at the time of cardiocirculatory arrest in the donor.	7 days	Delayed recovery of renal function will be confirmed if the recipient undergoes dialysis within the first 7 days after transplantation. Hypoxemia is defined as a PaO2 less than or equal to the median value.

Trial Locations

Locations (19)

CHU ANGERS - Urgences - Coordination Prélèvements; 🇫🇷 Angers, France

CH ANNECY GENEVOIS - Réanimation médicale - Coordination Prélèvements multi-organes; 🇫🇷 Annecy, France

CH AVIGNON - CH Henri Duffaut - Réanimation polyvalente; 🇫🇷 Avignon, France

CHD Vendée - Les Oudairies - Médecine Intensive Réanimation -Coordination Prélèvements multi-organes; 🇫🇷 La Roche-sur-Yon, France

CHD Vendée - Les Oudairies - Médecine Intensive Réanimation; 🇫🇷 La Roche-sur-Yon, France

CHU LILLE - Hôpital Roger Salengro - Coordination prélèvements multi-organes; 🇫🇷 Lille, France

CHU LILLE - Hôpital Roger Salengro - Médecine Intensive Réanimation; 🇫🇷 Lille, France

CHU NANTES +- Médecine Intensive Réanimation; 🇫🇷 Nantes, France

CHU Nantes - Coordination prélèvement multi organes; 🇫🇷 Nantes, France

CHRU ORLEANS -Médecine Intensive Réanimation - Coordination Prélèvements multi-organes; 🇫🇷 Orléans, France

APHP Hôpital COCHIN - Coordination Prélèvements d'Organes et Tissus; 🇫🇷 Paris, France

APHP Hôpital COCHIN - Médecine Intensive Réanimation; 🇫🇷 Paris, France

CHU POITIERS - Anesthésie Réanimation - Coordination Prélèvements multi-organes; 🇫🇷 Poitiers, France

CH PERIGUEUX - Réanimation - Coordination Prélèvements Organes et Tissus; 🇫🇷 Périgueux, France

CHU RENNES - CHU Pontchaillou - Réanimation médicale; 🇫🇷 Rennes, France

CHRU TOURS - Hôpital Bretonneau - Coordination Prélèvements multi-organes; 🇫🇷 Tours, France

CHRU TOURS - Hôpital Bretonneau - Médecine Intensive Réanimation; 🇫🇷 Tours, France

CHBA Vannes-Auray - Réanimation Polyvalente; 🇫🇷 Vannes, France

CHU ANGERS - Réanimation médicale; 🇫🇷 Angers, France