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Clinical Trials/NCT03609333
NCT03609333
Completed
Not Applicable

Characterizing the cerebrovAscular Physiology of Optimal Mean Arterial Pressure Targeted Resuscitation in Hypoxic Ischemic Brain Injury After Cardiac Arrest

University of British Columbia1 site in 1 country20 target enrollmentNovember 12, 2016
ConditionsCardiac Arrest

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Cardiac Arrest
Sponsor
University of British Columbia
Enrollment
20
Locations
1
Primary Endpoint
Cerberal blood flow
Status
Completed
Last Updated
5 years ago

Overview

Brief Summary

Hypoxic ischemic brain injury is a devastating illness that occurs after cardiac arrest (the heart stopping) and can yield irreversible brain damage, often leading to death. The mainstay in therapy is to optimize the delivery of oxygen to the brain to help it recover. In patients with traumatic brain injury (similar to HIBI), the investigators are able to optimize oxygen delivery to the brain with the use of wires placed into the brain that sense the pressure and oxygen in the skull to find the ideal blood pressure for each individual patient. This strategy is associated with improved outcomes. The investigators are conducting a prospective study investigating whether the perfusion within proximity to the optimal MAP is associated with improved brain oxygenation and blood flow .

Registry
clinicaltrials.gov
Start Date
November 12, 2016
End Date
June 30, 2020
Last Updated
5 years ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Myp Sekhon

Principal Investigator

University of British Columbia

Eligibility Criteria

Inclusion Criteria

  • Confirmed cardiac arrest with return of spontaneous circulation \> 10 minutes
  • post resuscitation GCS \< 9

Exclusion Criteria

  • concurrent coagulopathy
  • prior history of TBI, intracranial hemorrhage, subarachnoid hemorrhage
  • anticipated cardiac catheterization within next 7 days
  • anticipated or current use of anticoagulants or anit-platelets

Outcomes

Primary Outcomes

Cerberal blood flow

Time Frame: 12 hours

mls/100g/min

Study Sites (1)

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