Evaluation of Cerebral Oxygenation and Hemodynamics in Patients With Cerebral Venous Thrombosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 17
- 试验地点
- 1
- 主要终点
- Ipsilateral Regional Cerebral Oxygen Saturation
研究概览
简要总结
Cerebral hypoperfusion and hypoxia are the major determinants of neurological outcomes following acute brain injury as proved in Traumatic Brain Injury/Sub Arachnoid Haemhorrhage literature. How the brain injury affects cerebral oxygenation in patients with CVT is not currently known. Some of the factors that can affect cerebral oxygenation in patients with CVT are Hemoglobin, PO2, PCO2, Cerebral Perfusion Pressure (or MAP) and change in Intracranial Pressure after Decompressive Craniectomy. This study is designed to study how these factors affect cerebral oxygenation and impact of Decompressive Craniectomy on the cerebral oxygenation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed with cerebral venous thrombosis, undergoing decompressive craniectomy.
排除标准
- •Patients on inotropic support
- •Systolic blood pressure < 90 mmHg
- •Haemoglobin oxygen saturation <95%
- •Refusal of consent
- •Age <16 and > 65 years
- •Known history of diabetes or hypertension
- •Pregnancy
- •Any contraindication for application of cerebral oximetry sensors
结局指标
主要结局
Ipsilateral Regional Cerebral Oxygen Saturation
时间窗: From Recruitment till 48 hours postoperative (end of study)
Measurement of regional cerebral oxygen saturation over ipsilateral frontal lobe before and after decompressive craniectomy with follow up at postoperative 24 and 48 hours.
次要结局
- Systolic Blood Pressure(From Recruitment till 48 hours postoperative (end of study))
- Glasgow coma scale score(From Recruitment till 48 hours postoperative (end of study))
- Arterial blood gas measurement(From Recruitment till 48 hours postoperative (end of study))
- Contralateral Regional Cerebral Oxygen Saturation(From Recruitment till 48 hours postoperative (end of study))
- Haemoglobin(From Recruitment till 48 hours postoperative (end of study))
研究者
Dhritiman Chakrabarti
Assistant Professor
National Institute of Mental Health and Neuro Sciences, India