The Proactive Diagnostic Value of Hemostatic Biomarkers in Disseminated Intravascular Coagulation
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 462
- 试验地点
- 1
- 主要终点
- whether DIC occured
研究概览
简要总结
The project was undertaking by Qilu Hospital of Shandong University, aiming to evaluate diagnostic performance of hemostatic biomarkers in disseminated intravascular coagulation.
详细描述
Disseminated intravascular coagulation (DIC) is a life-threatening condition with high mortality, necessitating timely and accurate diagnosis for effective management. However, current diagnostic systems can not recognize DIC at its reversible phase, causing suboptimal treatment outcomes. Consequently, the current diagnostic criteria for DIC lacks earlier laboratory indicators. Therefore, the investigators aimed to assess the diagnostic potential of selected hemostatic biomarkers, including thrombin-antithrombin complex (TAT), soluble thrombomodulin (sTM), tissue plasminogen activator inhibitor complex (tPAI-C), α2-plasmin inhibitor plasmin complex (PIC) and anti-thrombin III (ATIII), in evaluating DIC, allowing for proactive diagnosis before the disease progresses into its irreversible phase.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 94 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years old, non-perinatal period, a hospitalization length of≥3 days.
排除标准
- •primary hematologic diseases, decompensated liver cirrhosis, chemotherapy history.
结局指标
主要结局
whether DIC occured
时间窗: From date of detecting hemostatic biomarkers until the date of first ISTH-DIC scores ≥5, assessed up to 7 days.
DIC includes pre-DIC and overt-DIC
次要结局
- whether death occurred(From date of admission until the date of death, assessed up to 5 months)
研究者
Miao Xu, MD
Principal Investigator
Qilu Hospital of Shandong University